Mechanistic modeling integrates preclinical and clinical data to simulate how multiple drugs interact within the body and influence pharmacokinetics, pharmacodynamics, and efficacy. It provides a structured framework for generating data-driven predictions for combination therapies, dosing strategies, and patient selection.
Key Questions This Service Can Answer:
- Which combination therapies are most likely to produce synergistic effects?
- What dosing schedules optimize efficacy while minimizing toxicity?
- How do patient characteristics influence response to combination therapy?
Case Studies
PBPK/RO modeling for anti-TIGIT mAbs
QSP model to guide dose selection for bsAb GEN1046
