2026
ChinaBio 2026, Shanghai, China
Optimization of step-up dosing regimen of T-cell engagers to mitigate cytokine release syndrome using quantitative systems pharmacology modeling: tarlatamab case study
Authors: Oleg Demin Jr, Galina Saynukova, Dmitry Shchelokov
QSPC 2026, Leiden, The Netherlands
Application of an AI Framework to Update a Quantitative Systems Pharmacology Model of CAR-T Therapy
Authors: Igor Goryanin (1,2), Oleg Demin (3), Irina Goryanin (2)
Affiliation: (1) Artificial Intelligence Institute, School of Informatics, University of Edinburgh, (2) IQANOVA Ltd., Edinburgh, (3) InSysBio
Integration of Genome-Scale Metabolism and Quantitative Immune Databases Enables AI-Driven QSP Modeling: An Asthma Case Study Using EHMN 2026
Authors: Igor Goryanin (1,2), Oleg Demin (3), Irina Goryanin (2)
Affiliation: (1) Artificial Intelligence Institute, School of Informatics, University of Edinburgh, (2) IQANOVA Ltd., Edinburgh, (3) InSysBio
Mixed-Integer Optimization for Virtual Population Selection in QSP Models
Authors: Ivan Borisov, Evgeny Metelkin
A QSP model for LNP-mRNA delivery reveals decoupled determinants of mRNA and encoded protein kinetics
Authors: Veronika Musatova (1), Anastasiia Ivanova (1), Kseniia Kudriavtseva (1), Oleg Demin (2), Rajat Desikan (3)
Affiliation: (1) InSysBio CY; (2) InSysBio UK; (3) Clinical Pharmacology Pharmacometric Systems and Tools, Platform Sciences, GSK, UK
When Good Fits Are Not Enough: Practical Identifiability with LikelihoodProfiler.jl
Authors: Ivan Borisov, Evgeny Metelkin
Mechanistic modeling of cytotoxicity mechanisms of antibodies to the CD20 receptor in relation to B lymphocytes
Authors: Dmitrii Gordeev, Tatiana Karelina, Oleg Demin
Model-Informed Prediction of First-in-Human Starting Dose and Step-Up Regimen for a T-Cell Engager
Authors: Oleg Demin Jr, Galina Saynukova, Dmitry Shchelokov
2025
ACoP 2025, Aurora, CO, US
From Data to Parameters: FIVEDB as a Tool for Efficient QSP Model Calibration
Authors: Ekaterina Goryacheva, Anna Kopeykina, Almina Polinova, Violetta Polinova, Nail Gizzatkulov, Oleg Demin
Enhancing QSP Model Creation and Validation with Cytoсon DB: A Standardized Repository for In Vivo Cell and Cytokine Baseline Concentrations
Authors: Vladislav Leonov, Ekaterina Mogilevskaya, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
JuliaCon Local Paris 2025, France
LikelihoodProfiler.jl: Practical Identifiability and Predictability Analysis in Julia
Authors: Ivan Borisov, Evgeny Metelkin
PAGE 2025, Thessaloniki, Greece
Enhancing QSP Model Creation and Validation with CYTOCON DB: A Standardized Repository for In Vivo Cell and Cytokine Baseline Concentrations
Authors: Vladislav Leonov, Ekaterina Mogilevskaya, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
LikelihoodProfiler.jl: A Unified Package for Practical Identifiability Analysis and Confidence Intervals Estimation
Authors: Ivan Borisov, Aleksander Demin, Evgeny Metelkin
AACR Annual Meeting 2025, Chicago, Illinois, US
Predicting the starting dose and step-up regimen for first-in-human trial of T-cell engagers using mechanistic mathematical modeling
Authors: Oleg Demin Jr, Galina Kolesova, Dmitry Shchelokov
Assessing strategies to activate DNAM1 signaling and inhibit the TIGIT/PVRIG axis using mathematical modeling
Authors: Oleg Demin Jr, Galina Kolesova, Dmitry Shchelokov
Optimization of tarlatamab step-up dosing regimen to mitigate cytokine release syndrome using quantitative systems pharmacology modeling
Authors: Oleg Demin Jr, Galina Kolesova, Dmitry Shchelokov
