2026
AAIC 2026, London, UK
NIDB-3101, a Novel Biparatopic Anti-Tau Antibody: Characterization of its Pharmacokinetics, Pharmacodynamics and Tolerability
Authors: Nadia Anceriz (1), Susana Salgado-Pires (1), Roman Rösemann (2), Bruno Daubeuf (1), Adeline Lesnier (1), Laurence Chatel (1), Alizée Viandier (1), Pauline Lloveras (1), Eric Hatterer (1), Dmitry Shchelokov (3), Galina Saynukova (3), Oleg Demin Jr (3), Jean-Philippe Courade (4)
Affiliation: (1) Light Chain Bioscience - Novimmune SA, Geneva, Switzerland, (2) Granzer Regulatory Consulting & Services GmbH, Munich, Germany, (3) InSysBio CY Ltd, Limassol, Cyprus, (4) discoveric bio alpha Ltd, Pfäffikon, Schwyz, Switzerland
Model-based Comparison Of Tfr-mediated Transcytosis & FcRn-mediated Half-life Extension To Optimize Cns Antibody Dosing
Authors: Jean-Philippe Courade (1), Oleg Demin Jr (2), Dmitry Shchelokov (2), Galina Saynukova (2), Jean-François Ghersi-Egea (3)
Affiliation: (1) discoveric bio alpha Ltd., Pfäffikon, Schwyz, Switzerland, (2) InSysBio, Paphos, Cyprus, (3) BIP facility, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, UCBL1, Bron France.
UK-QSP Training Workshop 2026, Coventry, UK
Mixed-Integer Optimization for Virtual Population Selection in QSP
Authors: Ivan Borisov, Evgeny Metelkin
PAGE 2026, Dubrovnik, Croatia
Quantitative Systems Pharmacology Modeling to Explore Alternative Step-Up Dosing Regimens for Tarlatamab, a DLL3-Targeting T-Cell Engager
Authors: Dmitry Shchelokov, Oleg Demin Jr, Galina Saynukova
CYTOCON and fIVE DB: Freely Accessible Databases for Streamlining QSP Model Calibration and Validation
Authors: Vladislav Leonov, Anna Kopeykina, Almina Polinova, Violetta Polinova, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Ekaterina Mogilevskaya, Ekaterina Goryacheva, Oleg Demin
ChinaBio 2026, Shanghai, China
Optimization of step-up dosing regimen of T-cell engagers to mitigate cytokine release syndrome using quantitative systems pharmacology modeling: tarlatamab case study
Authors: Oleg Demin Jr, Galina Saynukova, Dmitry Shchelokov
QSPC 2026, Leiden, The Netherlands
Application of an AI Framework to Update a Quantitative Systems Pharmacology Model of CAR-T Therapy
Authors: Igor Goryanin (1,2), Oleg Demin (3), Irina Goryanin (2)
Affiliation: (1) Artificial Intelligence Institute, School of Informatics, University of Edinburgh, (2) IQANOVA Ltd., Edinburgh, (3) InSysBio
Integration of Genome-Scale Metabolism and Quantitative Immune Databases Enables AI-Driven QSP Modeling: An Asthma Case Study Using EHMN 2026
Authors: Igor Goryanin (1,2), Oleg Demin (3), Irina Goryanin (2)
Affiliation: (1) Artificial Intelligence Institute, School of Informatics, University of Edinburgh, (2) IQANOVA Ltd., Edinburgh, (3) InSysBio
Mixed-Integer Optimization for Virtual Population Selection in QSP Models
Authors: Ivan Borisov, Evgeny Metelkin
A QSP model for LNP-mRNA delivery reveals decoupled determinants of mRNA and encoded protein kinetics
Authors: Veronika Musatova (1), Anastasiia Ivanova (1), Kseniia Kudriavtseva (1), Oleg Demin (2), Rajat Desikan (3)
Affiliation: (1) InSysBio CY; (2) InSysBio UK; (3) Clinical Pharmacology Pharmacometric Systems and Tools, Platform Sciences, GSK, UK
When Good Fits Are Not Enough: Practical Identifiability with LikelihoodProfiler.jl
Authors: Ivan Borisov, Evgeny Metelkin
Mechanistic modeling of cytotoxicity mechanisms of antibodies to the CD20 receptor in relation to B lymphocytes
Authors: Dmitrii Gordeev, Tatiana Karelina, Oleg Demin
Model-Informed Prediction of First-in-Human Starting Dose and Step-Up Regimen for a T-Cell Engager
Authors: Oleg Demin Jr, Galina Saynukova, Dmitry Shchelokov
