InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, launches fIVE Calculator. Initially, fIVE DB (from In Vitro Experiments DataBase) is an InSysBio project for in vitro experiments information collection and processing. fIVE DB is designed for QSP modelers and scientists who deal with in vitro/ex vivo data analysis to simplify their hard work and avoid potential errors. Information collected in the database enables them to save time typically spent for gathering and processing of literature and available data.
Now InSysBio presents public beta release of fIVE Calculator which is a web application designed to automatically calculate kinetic parameters from in vitro experiments for modeling of biosystems. The Calculator contains the input fields for the details of in vitro experiments, measurement units and uncertainties. Time- and dose-dependent datasets allows yielding kbase/kmax and Emax/EC50 correspondingly.
Graphical representation helps to visualize the input data and highlights the points picked up by the user for parameters estimation. Parameters are calculated automatically and then displayed in the results table.
Alexander Stepanov, the developer of the Calculator comments on it, “Here we present Shiny application to demonstrate the features of the framework built-in in fIVE DB as well as to provide a possibility to estimate parameters without fitting from available in vitro experiments”.
fIVE Calculator available at https://step-by-step.shinyapps.io/five-db-calculator/
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Edinburgh, UK (INSYSBIO UK LIMITED), Limassol, Cyprus (INSYSBIO CY Ltd) and Moscow, Russia (INSYSBIO LLC). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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16 Dec 2021 13:02
The launch of fIVE DB facilitates calibration of biomodels
InSysBio now presents its new QSP modeling tool, fIVE DB. The name of the database derives from In Vitro Experiments DataBase. fIVE DB is a repository of kinetic data for Systems Biology Modeling.
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23 Dec 2021 17:13
InSysBio to update CYTOCON DB and CYTOCON DB Open
CYTOCON DB is a database of human baseline concentrations of cytokines and cells measured in different tissues. CYTOCON DB Open is a version of the database designed for public use.
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