Now the Immunological Synapse submodels are meaningfully improved

NEWS
Press-Release
Software
March 31, 2025

InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, launches Immune Response Template (IRT) version 3.7.0. IRT represents a QSP platform of immune system, simultaneously, being a tool for development of models related to immune system.

Generally, IRT is based on two main components. On the one hand, it is a fully-fledged database including a wide variety of features covering the immune system. On the other hand, it comprises Navigator that provides intuitive interface to interact with IRT Database. Thus, a modeler can apply calibrated submodels exported from IRT as building blocks to simplify the model development process.

IRT is a part of InSysBio’s QSP software infrastructure being under constant upgrade. IRT v.3.7.0 gets a range of new features:

  • Immunological Synapse submodels are updated. Each surface molecule now has degradation and synthesis velocities.
  • Immunological Synapse schemes are updated. Now they are more convenient and clearer. New details have also been added to the schemes.
  • Minor fixes have been added.

Veronika Musatova, Head of IRT development team, comments on the new version, “This update brings a meaningful improvement to the Immunological Synapse submodels. Introducing synthesis and degradation of each surface molecule, we add important biological dynamics, aligning the submodels more closely with real cellular behavior. These processes are commonly used in the development of QSP models to capture turnover and regulation mechanisms.”

To learn the full content of Immune Response Template, please visit irt.insysbio.com

To get demo access to IRT, please click “sign in” or “user account” on irt.insysbio.com

To get more information on any tool or leave your feedback, please feel free to contact us: support@insysbio.com

About InSysBio

InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s cutting-edge QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry and innovative biotech companies. For more information about InSysBio, its solutions and services, visit www.insysbio.com

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1. 19 May 2021 16:52 InSysBio to upgrade its SbmlViewer application [Moscow – 19.05.2021] InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, launches the new version (0.3.0) of its SbmlViewer open project. Generally, SbmlViewer is a tool for fast and easy reading and transformation of biological models written in SBML format.
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1. 25 May 2021 17:38 InSysBio to take part in SMB 2021 InSysBio announces its participation in Society of Mathematical Biology Annual Meeting (SMB 2021) which is to be held virtually this year June 13-17, 2021. InSysBio team is going to present 4 posters and Oleg Demin Jr is going to give a presentation "Implementation of variability or uncertainty in parameter values to validate QSP models." and Ivan Borisov is going to give a talk "Constrained Optimization Approach to Predictability Analysis in Bio-Mathematical Modeling."
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