January 16, 2023
The new article “Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study” by Dmitry Shchelokov and Oleg Demin Jr was published in mAbs journal at the end of December 2022.
Oleg Demin Jr comments on the article, “Mechanistic description of biomarkers and endpoints is necessary for accurate analysis of the clinical trial results and prediction of these outcomes by QSP modeling. One of these endpoints is target receptor occupancy which is measured in early clinical trials for therapeutic antibodies including monoclonal and bispecific ones, etc. In the published article we have shown that the method of target occupancy measurement can affect the results of clinical trials and their interpretation”.
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Edinburgh, UK (INSYSBIO UK LIMITED), Limassol, Cyprus (INSYSBIO CY Ltd) and Moscow, Russia (INSYSBIO LLC). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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03 Mar 2020 12:25
13th InSysBio Annual Internal Scientific Meeting
26-28 February 2020 InSysBio QSP-company held its 13th Annual Internal Scientific Meeting. InSysBio team presented the results of 2019 year professional progress. Every member demonstrated their personal achievements and shared the plans for the future development. Oleg Demin, InSysBio CEO and founder, summarized all the company’s advancement of the year 2019.
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10 Mar 2020 12:48
InSysBio to share the news from QSPC2020 management
Today we have received the concerning news from QSPC2020 organizers about the cancellation of the conference in response to COVID-19 outbreak continuation. Quantitative Systems Pharmacology Conference 2020 was planned to be held in April 22-24, 2020 Leiden, The Netherlands. InSysBio team was prepared to present 10 posters
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