January 16, 2023
The new article “Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study” by Dmitry Shchelokov and Oleg Demin Jr was published in mAbs journal at the end of December 2022.
Oleg Demin Jr comments on the article, “Mechanistic description of biomarkers and endpoints is necessary for accurate analysis of the clinical trial results and prediction of these outcomes by QSP modeling. One of these endpoints is target receptor occupancy which is measured in early clinical trials for therapeutic antibodies including monoclonal and bispecific ones, etc. In the published article we have shown that the method of target occupancy measurement can affect the results of clinical trials and their interpretation”.
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Edinburgh, UK (INSYSBIO UK LIMITED), Limassol, Cyprus (INSYSBIO CY Ltd) and Moscow, Russia (INSYSBIO LLC). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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04 Mar 2019 15:40
12th InSysBio Annual Internal Scientific Meeting
20-22 February 2019 InSysBio company held the 12th Annual Internal Scientific Meeting. Results of the last year and plans for the ongoing year were discussed.
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13 Mar 2019 15:50
Tatiana Karelina on TV
Tatiana Karelina, Head of the Alzheimer’s Disease modeling group at InSysBio participated in the Russian TV show «Us and science. Science and us».
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22 Mar 2019 14:58
InSysBio to present at AACR Annual Meeting 2019
InSysBio announces their participation at American Association for Cancer Research Annual Meeting 2019 being held on March 29 – April 3 in Atlanta, GA
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26 Mar 2019 19:51
InSysBio to present at PEGS Boston
InSysBio announces their participation at 15th Essential Protein Engineering Summit being held on April 8-12 in Boston, MA.
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