January 16, 2023
The new article “Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study” by Dmitry Shchelokov and Oleg Demin Jr was published in mAbs journal at the end of December 2022.
Oleg Demin Jr comments on the article, “Mechanistic description of biomarkers and endpoints is necessary for accurate analysis of the clinical trial results and prediction of these outcomes by QSP modeling. One of these endpoints is target receptor occupancy which is measured in early clinical trials for therapeutic antibodies including monoclonal and bispecific ones, etc. In the published article we have shown that the method of target occupancy measurement can affect the results of clinical trials and their interpretation”.
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Edinburgh, UK (INSYSBIO UK LIMITED), Limassol, Cyprus (INSYSBIO CY Ltd) and Moscow, Russia (INSYSBIO LLC). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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09 Nov 2023 16:15
IRT webinars. InSysBio ecosystem to speed up and facilitate QSP model development
InSysBio announces the upcoming webinar on Immune Response Template (IRT) on November 21 & 28, 2023 at 8am PST / 11am EST. This webinar aims to demonstrate how to use InSysBio ecosystem and IRT in particular to speed up and facilitate QSP model development.
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27 Nov 2023 17:45
InSysBio to announce a webinar on CYTOCON organized by ASCPT
InSysBio announces its participation in the upcoming webinar on CYTOCON organized by ASCPT entitled "CYTOCON: The Manually Curated Database of Human In Vivo Cell and Molecule Concentrations" on November 28, 2023, 9AM PT, 12PM ET. This webinar aims to demonstrate key features and application of CYTOCON DB.
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