The new article "Quantitative systems pharmacology model of α-synuclein pathology in Parkinson's disease-like mouse for investigation of passive immunotherapy mechanisms" by Olga Ivanova and Tatiana Karelina was published in PSPJournal at the end of August 2024.
Olga Ivanova comments on the article, "Our model of PD-like pathology in mice captures the complex dynamics of αSyn metabolism throughout the brain and the influence of neuroinflammation on PD pathogenesis and dopaminergic neurodegeneration. The model simulations predict how different proposed mechanisms of anti-αSyn immunotherapy may contribute to pathology reduction and how anti-inflammatory therapy may enhance the effect of immunotherapy."
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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10 Nov 2020 16:33
InSysBio to release Demo Version of Immune Response Template
[Moscow – 10.11.2020] InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, presents the new access mode to Immune Response Template (IRT) version 3. Now any modeler can experience or get acquainted with IRT via Demo access without the necessity to purchase the license.
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12 Nov 2020 16:36
InSysBio to release CYTOCON DB Open version
CYTOCON DB Open is designed for free public use
[Moscow – 12.11.2020] InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, has extended the variety of options to experience its CYTOCON DB with a new way. In general, the database allows to investigate the concentration of multiple species measured in different tissues of patients. Now InSysBio presents its public version entitled “CYTOCON DB Open”.
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27 Nov 2020 12:45
InSysBio to run Heta video tutorial on YouTube
InSysBio has recently launched weekly series on YouTube about the Heta language.
Heta is a modeling language for quantitative systems pharmacology and systems biology. Now InSysBio presents the tutorial consisting of short lessons that familiarize with Heta, describe its features and show examples.
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