The new article "Quantitative systems pharmacology model of α-synuclein pathology in Parkinson's disease-like mouse for investigation of passive immunotherapy mechanisms" by Olga Ivanova and Tatiana Karelina was published in PSPJournal at the end of August 2024.
Olga Ivanova comments on the article, "Our model of PD-like pathology in mice captures the complex dynamics of αSyn metabolism throughout the brain and the influence of neuroinflammation on PD pathogenesis and dopaminergic neurodegeneration. The model simulations predict how different proposed mechanisms of anti-αSyn immunotherapy may contribute to pathology reduction and how anti-inflammatory therapy may enhance the effect of immunotherapy."
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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06 Oct 2020 16:44
InSysBio to release the new version of DBSolveOptimum
DBSolveOptimum 2020 provides extended opportunities for QSP modeling
[Moscow, Russia – 06.10.2020] InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, releases the new version of mathematical simulation workbench DBSolveOptimum 2020. It represents a significantly advanced and extended successor of the well-known simulation software DBSolveOptimum described in the paper [PMID 20698988] published in 2010. DBSolve is a user friendly simulation software package that enables to simplify the development, calibration and analysis of QSP models.
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16 Oct 2020 15:50
InSysBio to upgrade its Cytocon DB
Latest news about Cytocon DB! Its new version 1.3.6.8 got a number of principal update
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