September, 2023
InSysBio announces its participation in SITC's 38th Annual Meeting (the Society for Immunotherapy of Cancer) which is to be held on November 1 - 5, 2023 at San Diego Convention Center, San Diego, California or Virtual. InSysBio team is going to present its Mechanistic modeling services and tools to support development of immunotherapies at Booth #1133 and 6 posters in frames of the Meeting, namely:
338 "Comparison of lymphodepleting chemotherapy regimens as preconditioning for T-cell therapies via mathematical modeling" by Oleg Demin Jr1, Galina Kolesova2, Natalia Ramos Hernandez3, Thomas Faitg3, Stefan Zajic3, Lourdes Cucurull-Sanchez4
Affiliation: (1) InSysBio CY, Paphos, Cyprus; (2) InSysBio, Moscow, Russia; (3) GlaxoSmithKline, Collegeville, PA 19426, USA; (4) GlaxoSmithKline, Stevenage, Hertfordshire, UK
354 "Optimization of dose and regimen of letetresgene autoleucel for the treatment of synovial sarcoma: simulation of dose dependence and split dosing using quantitative systems pharmacology modeling" by Oleg Demin Jr1, Galina Kolesova2, Stefan Zajic3, Lourdes Cucurull-Sanchez4
Affiliation: (1) InSysBio CY, Paphos, Cyprus; (2) InSysBio, Moscow, Russia; (3) GlaxoSmithKline, Collegeville, PA 19426, USA; (4) GlaxoSmithKline, Stevenage, Hertfordshire, UK
480 "Translational PK/RO model of tetravalent bispecific antibody CTX8371: receptor occupancy estimation, PD1 loss and bispecific binding-related avidity increase in low doses" by Veronika Musatova, Oleg Demin Jr, Dmitry Shchelokov, Oleg Demin
Affiliation: (1) InSysBio CY, Paphos, Cyprus; (2) InSysBio UK, Edinburgh, UK; (3) Genmab US, Inc, Plainsboro, N
1167 "Prediction of first-in-human dose for HPN536, a T-cell engager targeting mesothelin: MABEL vs mechanistic translational PK/RO/PA modeling" by Oleg Demin Jr, Dmitry Shchelokov
1280 "Modeling of direct (EGFR- based) and ADCC cytotoxic effect of Cetuximab on the basis of literature available in vitro data" by Oleg Demin2, Sergey Smirnov1, Alexandra Diakonova1, Anna Roskoshnaya1, Gaurav Bajaj3, Homer Adams III3, Manish Gupta3, Craig Thalhauser3
Affiliation: (1) InSysBio CY, Paphos, Cyprus; (2) InSysBio UK, Edinburgh, UK; (3) Genmab US, Inc, Plainsboro N
Check out our Booth #1133 at SITC 2023!
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Edinburgh, UK (INSYSBIO UK LIMITED), Limassol, Cyprus (INSYSBIO CY Ltd) and Moscow, Russia (INSYSBIO LLC). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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09 Nov 2023 16:15
IRT webinars. InSysBio ecosystem to speed up and facilitate QSP model development
InSysBio announces the upcoming webinar on Immune Response Template (IRT) on November 21 & 28, 2023 at 8am PST / 11am EST. This webinar aims to demonstrate how to use InSysBio ecosystem and IRT in particular to speed up and facilitate QSP model development.
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27 Nov 2023 17:45
InSysBio to announce a webinar on CYTOCON organized by ASCPT
InSysBio announces its participation in the upcoming webinar on CYTOCON organized by ASCPT entitled "CYTOCON: The Manually Curated Database of Human In Vivo Cell and Molecule Concentrations" on November 28, 2023, 9AM PT, 12PM ET. This webinar aims to demonstrate key features and application of CYTOCON DB.
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