InSysBio to present at ACoP10

2 1. 02 Jun 2020 13:24 InSysBio to announce the launch of QSP model of COVID-19 The new open source project to be developed and updated Online InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, announces the launch of its fundamentally new project in response to the ongoing global threat, the open source QSP model of COVID-19. In accordance with its mission, which is to assist pharmaceutical industry to speed up the delivery of the cure to patients, InSysBio team could not stay aside. Thus, the aim of the new project is to develop QSP model of COVID-19 describing virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.

5 1. 05 Jun 2020 15:04 InSysBio to present IRT Navigator 3 InSysBio presents IRT Navigator 3 which is an application software providing intuitive interface to work with the Immune Response Template Database in accordance with the user’s needs. It supplies the navigation within the schemes and components and efficient development of QSP models based on IRT Database.

8 1. 08 Jun 2020 15:30 InSysBio to perform the first step in development of COVID-19 QSP model InSysBio has performed the first step in the direction of development of QSP model of COVID-19 describing virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.

12 1. 12 Jun 2020 16:45 InSysBio to release the new version of Cytocon DB 1.1.6.4 We are glad to announce the release of the new version of Cytocon DB 1.1.6.4. The DB was significantly extended with new data due to well-coordinated workflow of Cytocon DB team and its new members. Namely, 54 diseases, 24 tissues, 42 molecules, 24 cells and 3701 concentrations were introduced.

17 1. 17 Jun 2020 15:48 InSysBio to welcome its new team member Dr. Neil Benson InSysBio announces the appointment of Dr. Neil Benson as Principal Consultant in area of business development (Edinburgh-Moscow-16.06.2020) InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, is proud to announce its new team member Dr. Neil Benson! Dr. Benson has joined InSysBio as Principal Consultant in area of business development of both INSYSBIO LLC and INSYSBIO UK LIMITED. In his capacity as Principal Consultant to InSysBio, he will support further development of the outstanding IO and AD QSP offering of the company.

22 1. 22 Jun 2020 17:04 InSysBio team posters to be presented at AACR Virtual Annual Meeting II AACR Virtual Annual Meeting II has begun! American Association for Cancer Research Annual Meeting is held virtually this year on June 22-24 due to COVID-19 spread. Today InSysBio team's posters were published on AACR website

30 1. 30 Jun 2020 15:45 InSysBio to present COVID-19 QSP model further development InSysBio continues to move forward in COVID-19 QSP model development. Its aim is to describe virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.

events

Conference

September 18, 2019

September 18, 2019

InSysBio announces their participation at Tenth American Conference on Pharmacometrics (ACoP10) to be held October 20th to 23rd, 2019, at the Rosen Shingle Creek Hotel in Orlando, FL. The theme of ACoP10 is “Modeling without Borders.”.

Tatiana Karelina, lead modeler in Alzheimer’s Disease, will make an oral presentation “AD pathology QSP platform: studying the interactions between different toxicity modules through the junction of mechanistic submodels” in framework of the concurrent session 2b “QSP modeling in Neuroscience: Novel Technologies and Methodologies” on Monday, 2:00 pm.

InSysBio welcomes visitors at the booth # 11. Also InSysBio team will present twelve posters at the Conference:

Monday, October 21:

M-066: “Physiologically based pharmacokinetic and receptor occupancy (PBPK/RO) modeling of anti-PD1 monoclonal antibodies” by Oleg Demin Jr and Dmitry Shchelokov
M-074: “Investigation of bell-shaped dose response of bispecific T-cell engaging antibodies under physiological conditions” by Oleg Demin Jr
M-087: “Quantitative systems pharmacology model of COPD progression with implemented standard of care treatments (LABA/ ICS)” by Galina Lebedeva, Mikhail Benkov, Oleg Demin, Loveleena Bansal (GSK), Cibele Falkenberg (GSK), Martin Hingle (GSK) and Valeriu Damian (GSK)

Tuesday, October 22:

T-062: “LikelihoodProfiler Is a Software Package for Practical Identifiability Analysis for the Large-Scale Dynamic Models” by Ivan Borisov and Evgeny Metelkin
T-075: “Development of quantitative systems pharmacology (QSP) model of systemic lupus erythematosus and its application to explore possible mechanisms of alterations in serum IFN1 resulting from anti-IFNAR1 treatment” by Sergey Smirnov, Alexsandra Diakonova, Oleg Demin, Christopher Morehouse (MedImmune), Dominic Sinibaldi (MedImmune), Raj Tummala (AstraZeneca), Denison Kuruvilla (MedImmune), Yen Len Chia (MedImmune), Lorin K. Roskos (MedImmune) and Wendy I. White (MedImmune)
T-087: “Influence of neuronal protein degradation pathways on tau pathology studied by Quantitative Systems Pharmacology model” by Tatiana Karelina, Mark Meerson and Diana Klausznitzer (AbbVie)
T-089: “From stem cell to erythrocyte and platelet: QSP model of erythropoiesis and thrombopoiesis for assessing the impact of pharmacological interventions” by Alexander Stepanov and Galina Lebedeva
T-094: “Workflow for development of QSP models of Immune Response requires appropriate software infrastructure” by Oleg Demin, Sergey Smirnov, Galina Lebedeva, Oleg Demin Jr, Evgeny Metelkin and Nail Gizzatkulov
T-099: “’Heta’ is a New Declarative Language to Define the Large-Scale Systems Pharmacology and Systems Biology Models” by Evgeny Metelkin

Wednesday, October 23:

W-066: “PBPK modeling for therapeutic nanoparticles loaded with drug: distribution and release” by Evgeny Metelkin and Oleg Demin
W-072: “In vitro to in vivo extrapolation of CD4 T cell polarization in lymph nodes using QSP Modeling” by Oleg Demin, Svetlana Rubina, Dmitry Shchelokov and Oleg Demin Jr
W-080: “QSP model of human granulopoiesis and neutrophil homeostasis for assessment of pharmacological interventions” by Galina Lebedeva and Alexander Stepanov.

About InSysBio

InSysBio is a Quantitative Systems Pharmacology (QSP) company located in Moscow, Russia (INSYSBIO LLC) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative approach has already become a part of the drug development process implemented by our strategic partners: nowadays there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. The company has published multiple scientific studies in various therapeutic areas. InSysBio team is developing software and tools for QSP and continuously improves methods for biological modeling. For more information about InSysBio, its solutions and services, visit insysbio.com.

←	June 2020	→
Mo	Tu	We	Th	Fr	Sa	Su
1	2 1. 02 Jun 2020 13:24 InSysBio to announce the launch of QSP model of COVID-19 The new open source project to be developed and updated Online InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, announces the launch of its fundamentally new project in response to the ongoing global threat, the open source QSP model of COVID-19. In accordance with its mission, which is to assist pharmaceutical industry to speed up the delivery of the cure to patients, InSysBio team could not stay aside. Thus, the aim of the new project is to develop QSP model of COVID-19 describing virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.	3	4	5 1. 05 Jun 2020 15:04 InSysBio to present IRT Navigator 3 InSysBio presents IRT Navigator 3 which is an application software providing intuitive interface to work with the Immune Response Template Database in accordance with the user’s needs. It supplies the navigation within the schemes and components and efficient development of QSP models based on IRT Database.	6	7
8 1. 08 Jun 2020 15:30 InSysBio to perform the first step in development of COVID-19 QSP model InSysBio has performed the first step in the direction of development of QSP model of COVID-19 describing virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.	9	10	11	12 1. 12 Jun 2020 16:45 InSysBio to release the new version of Cytocon DB 1.1.6.4 We are glad to announce the release of the new version of Cytocon DB 1.1.6.4. The DB was significantly extended with new data due to well-coordinated workflow of Cytocon DB team and its new members. Namely, 54 diseases, 24 tissues, 42 molecules, 24 cells and 3701 concentrations were introduced.	13	14
15	16	17 1. 17 Jun 2020 15:48 InSysBio to welcome its new team member Dr. Neil Benson InSysBio announces the appointment of Dr. Neil Benson as Principal Consultant in area of business development (Edinburgh-Moscow-16.06.2020) InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, is proud to announce its new team member Dr. Neil Benson! Dr. Benson has joined InSysBio as Principal Consultant in area of business development of both INSYSBIO LLC and INSYSBIO UK LIMITED. In his capacity as Principal Consultant to InSysBio, he will support further development of the outstanding IO and AD QSP offering of the company.	18	19	20	21
22 1. 22 Jun 2020 17:04 InSysBio team posters to be presented at AACR Virtual Annual Meeting II AACR Virtual Annual Meeting II has begun! American Association for Cancer Research Annual Meeting is held virtually this year on June 22-24 due to COVID-19 spread. Today InSysBio team's posters were published on AACR website	23	24	25	26	27	28
29	30 1. 30 Jun 2020 15:45 InSysBio to present COVID-19 QSP model further development InSysBio continues to move forward in COVID-19 QSP model development. Its aim is to describe virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.

Upcoming Events

04.06

InSysBio to take part in PAGE 2025