From Literature to Model-Ready Data: Cutting Weeks Off Your QSP Workflow

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Software
April 15, 2026

InSysBio announces the upcoming webinar on the New Data Annotation Service for CYTOCON DB & fIVE DB on May 19, 2026, 16:00 CEST / 10:00 ET (Microsoft Teams).

Stop mining PubMed. Start modeling.

Before the first equation is written, QSP modelers face a data problem. Sourcing reliable baseline concentrations, extracting kinetic parameters from in vitro studies, standardizing units across dozens of papers, deciding which values to trust — this work typically consumes 4–8 weeks per project, delays model development, and inflates costs.

InSysBio has built two purpose-designed databases to address this bottleneck.

CYTOCON DB is a manually curated database of human in vivo cell and cytokine concentrations: 551 disease types, 253 tissues, 813 molecules, 301 cell types, and over 112,000 standardized data points extracted from nearly 3,000 published sources. Content grows by approximately 1,500 values per month.

fIVE DB captures quantitative parameters derived from in vitro and ex vivo experiments on cell processes — secretion, proliferation, cell death, migration, differentiation, and cytokine degradation — with over 43,000 parameters extracted from 2,247 sources, pre-processed into forms directly usable in mathematical models.

For projects requiring data beyond existing database coverage — rare indications, novel targets, or expanded parameter sets — InSysBio's Data Annotation Service delivers custom, expert-curated datasets within 30 days.

This webinar walks through what each database contains, how the data maps to QSP calibration and virtual patient workflows, and when custom annotation fills the gaps.

WHAT YOU'LL LEARN

  • Why manual literature curation remains the biggest time sink in QSP projects and what it actually costs
  • What CYTOCON DB and fIVE DB contain, how they're organized, and how they're updated
  • How standardized database outputs connect to model calibration and virtual patient generation
  • When and how InSysBio's Data Annotation Service complements database coverage for bespoke projects

Speaker: Vladislav Leonov, CYTOCON DB and fIVE DB Manager.

REGISTER HERE

About InSysBio

InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio's cutting-edge QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry and innovative biotech companies. For more information about InSysBio, its solutions and services, visit www.insysbio.com

July 2020
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1. 06 Jul 2020 17:37 InSysBio to announce the launch of its new tool Heta compiler Heta compiler has been published on GitHub as an OpenSource (Moscow-06.07.2020) InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, presents Heta compiler which is a tool for the development of Quantitative Systems Pharmacology and Systems Biology platforms. Particularly, it allows combining modules written in different formats like: Heta language code, Excel sheets, JSON, YAML formatted structures, SBML and transforming them into the dynamic models of different formats.
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1. 27 Jul 2020 11:45 InSysBio to evolve its Open Source QSP model of COVID-19 InSysBio has presented a new portion of results in the framework of development of COVID-19 QSP model.
2. 27 Jul 2020 16:42 InSysBio to present its posters at AAIC 2020 Virtual Event InSysBio announces its participation in AAIC 2020 Virtual Event. Alzheimer's Association International Conference is held virtually on July 27-31. InSysBio team presents two posters within its frames
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