2019
SITC 2019, National Harbor, MD, US
Prediction of target occupancy in tumor after treatment with anti-PD1 antibodies using physiologically based pharmacokinetic modeling
Authors: Oleg Demin Jr, Dmitry Shchelokov
Quantitative systems pharmacology modeling of B-cell acute lymphoblastic leukemia treatment with bispecific T-cell engaging antibodies for investigation of bell-shaped dose response
Authors: Oleg Demin Jr
PEGS 2019, Boston, MA, US
Selection of First-in-Human Study Dose for Antibodies and Antibody Constructs Using Quantitative Systems Pharmacology Modeling
Authors: Oleg Demin Jr, Dmitry Shchelokov
PAGE 2019, Stockholm, Sweden
Quantitative Systems Pharmacology model of key intraneuronal pathways regulating toxic protein accumulation
Authors: Mark Meerson1, Tatiana Karelina1 and Diana Сlausznitzer2
Affiliation: 1InSysBio, Moscow, Russia, 2AbbVie, Ludwigshaven, Germany
Physiologically based pharmacokinetic modeling of anti-PD-1 therapeutic antibodies
Authors: Dmitry Shchelokov, Oleg Demin Jr
Amyloid ? in vitro prion properties and in vivo pathology exacerbation mechanisms studied by translation quantitative systems pharmacology model for prediction of anti-protofibril immunotherapy effects
Authors: Tatiana Karelina
Application of different approaches to generate virtual patient populations for QSP model of physiologically based pharmacokinetic model of anti-PD-1 therapeutic antibodies
Authors: Galina Kolesova, Oleg Demin, Evgeny Metelkin and Dmitry Shchelokov
AACR Annual Meeting 2019, Atlanta, GA, US
Quantitative systems pharmacology modeling of immunotherapies in B-cell acute lymphoblastic leukemia
Authors: Oleg Demin Jr, Antonina Nikitich, Oleg Demin
Implementation of inter-patient variability in semi-mechanistic model of melanoma treatment with vemurafenib
Authors: Dmitry Shchelokov, Oleg Demin Jr, Oleg Demin
2018
BiotechClub, Moscow, Russia
Application of mathematical modeling in drug research and development
Speaker: Oleg Demin
Application of QSP modeling in immuno-oncology
Speaker: Oleg Demin Jr
ICSB 2018, Lyon, France
SBML viewer is a tool for transformation of systems biology models to human-readable format
Authors: Viktoria Tkachenko , Evgeny Metelkin
An algorithm for practical identifiability analysis and confidence intervals evaluation based on constrained optimization
Authors: Ivan Borisov, Evgeny Metelkin
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