PEGS 2019, Boston, MA, US
Selection of First-in-Human Study Dose for Antibodies and Antibody Constructs Using Quantitative Systems Pharmacology Modeling
Authors: Oleg Demin Jr, Dmitry Shchelokov
PAGE 2019, Stockholm, Sweden
Quantitative Systems Pharmacology model of key intraneuronal pathways regulating toxic protein accumulation
Authors: Mark Meerson1, Tatiana Karelina1 and Diana Сlausznitzer2
Affiliation: 1InSysBio, Moscow, Russia, 2AbbVie, Ludwigshaven, Germany
Physiologically based pharmacokinetic modeling of anti-PD-1 therapeutic antibodies
Authors: Dmitry Shchelokov, Oleg Demin Jr
Amyloid ? in vitro prion properties and in vivo pathology exacerbation mechanisms studied by translation quantitative systems pharmacology model for prediction of anti-protofibril immunotherapy effects
Authors: Tatiana Karelina
Application of different approaches to generate virtual patient populations for QSP model of physiologically based pharmacokinetic model of anti-PD-1 therapeutic antibodies
Authors: Galina Kolesova, Oleg Demin, Evgeny Metelkin and Dmitry Shchelokov
AACR Annual Meeting 2019, Atlanta, GA, US
Quantitative systems pharmacology modeling of immunotherapies in B-cell acute lymphoblastic leukemia
Authors: Oleg Demin Jr, Antonina Nikitich, Oleg Demin
Implementation of inter-patient variability in semi-mechanistic model of melanoma treatment with vemurafenib
Authors: Dmitry Shchelokov, Oleg Demin Jr, Oleg Demin
BiotechClub, Moscow, Russia
Application of mathematical modeling in drug research and development
Speaker: Oleg Demin
Application of QSP modeling in immuno-oncology
Speaker: Oleg Demin Jr
ICSB 2018, Lyon, France
SBML viewer is a tool for transformation of systems biology models to human-readable format
Authors: Viktoria Tkachenko , Evgeny Metelkin
An algorithm for practical identifiability analysis and confidence intervals evaluation based on constrained optimization
Authors: Ivan Borisov, Evgeny Metelkin
ACoP9, San Diego, CA, US
Quantitative systems pharmacology model for amyloid pathology investigation
Authors: Tatiana Karelina
Quantitative Systems Pharmacology (QSP) model of bispecific T-Cell engaging antibody constructs for Acute Myeloid Leukemia treatment
Authors: Oleg Demin Jr1, Svetlana Rubina1, Theresa Yuraszeck2, Khamir Mehta2, Vaishali Chudasama2, Matthias Klinger3, Cedric Dos Santos2, Oleg Demin1, Sergey Ermakov2
Affiliation: 1InSysBio, Moscow, Russia; 2Amgen Inc., Thousand Oaks, CA, USA; 3Amgen Research (Munich), Germany
Translational quantitative systems pharmacology model of tau pathology in human and mouse for immunotherapy investigation
Authors: Tatiana Karelina, Alexander Stepanov
Identification of parameters of QSP models responsible for observed variability in experimental data
Authors: Galina Kolesova, Oleg Demin