2022
Quantitative Systems Pharmacology for Immuno-Oncology, Cambridgeshire, UK
Specific aspects of the implementation of different combination therapies in the QSP model: focus on the data
Authors: Oleg Demin Jr
QSPC 2022, Leiden, The Netherlands
Heta project
Authors: Evgeny Metelkin
Method to describe multiple effects of regulatory molecules on cell dynamics process in QSP models of immune response
Authors: Oleg Demin, Sergey Smirnov, Galina Lebedeva
Collection of methodological findings for QSP model development
Authors: Oleg Demin, Maria Mironovich, Julia Sergienko
CYTOCON DB as a tool to store and analyze in vivo human concentrations of cells and molecules
Authors: Ekaterina Mogilevskaia, Vladislav Leonov, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
Comparison Of Different Approaches To Generate Virtual Patient Populations Of Different Sizes For QSP Model Of Erythropoiesis
Authors: Galina Kolesova, Oleg Demin, Alexander Stepanov
Confidence Intervals by Constrained Optimization – a Single Algorithm for Identifiability and Predictability Analysis in Systems Biology
Authors: Ivan Borosov, Evgeny Metelkin
QSP model that describes neurofilament L protein dynamics in Alzheimer’s disease
Authors: Polina Pchelintseva, Tatiana Karelina, Oleg Demin
Application of Immune Response Template (IRT) to the COVID19 QSP platform prototype development
Authors: Veronika Musatova, Oleg Demin, Anna Viktorenko, Anastasia Ivanova
Stimulation of erythropoiesis with ESA or blood donation: QSP model
Authors: Alexander Stepanov, Galina Lebedeva
QSP Modeling of Thrombopoiesis and Essential Thrombocythemia Treatment
Authors: Svetlana Rubina (1), Artem Ivanov (2), Galina Lebedeva (1)
Affiliation: (1) InSysBio, Moscow, Russia, (2) Lomonosov Moscow State University, Moscow, Russia
Dynamic and reproducible reports for QSP modeling in R and Julia: working examples
Authors: Evgeny Metelkin, Ivan Borisov
fIVE Database is a repository of in vitro data and estimates of kinetic parameters for systems modeling
Authors: Alexander Stepanov, Veronika Musatova, Anna Victorenko, Ekaterina Goryacheva, Nail Gizzatkulov, Oleg Demin
QSP model of human granulopoiesis and neutrophil homeostasis under growth factor, stem-cell mobilizing and cytotoxic therapies
Authors: Galina Lebedeva, Alexander Stepanov
Exploration of potential efficacy of tau-targeting immunotherapy and simulation of combination of immunotherapies targeting tau and amyloid using QSP approach
Authors: Tatiana Karelina, Polina Pchelintseva, Oleg Demin
Prediction of pharmacokinetics and optimal dose for a bispecific antibody against CD40 and PD1
Authors: Alexandra Diakonova, Oleg Demin Jr, Dmitry Shchelokov, Oleg Demin
AACR Annual Meeting 2022, New Orleans, Louisiana, US
Prediction of pharmacokinetics and receptor occupancy of a bispecific antibody against CD40 and PD-L1
Authors: Alexandra Diakonova, Oleg Demin Jr., Dmitry Shchelokov, Oleg Demin
Prediction of intratumoral TIGIT receptor occupancy after the treatment with anti-TIGIT antibodies
Authors: Dmitry Shchelokov (1), Oleg Demin Jr (1), Oleg Demin (1), Ahsan Rizwan (2), Yun Zhang (3), Wei Tan (4), Srikumar Sahasranaman (2), Nageshwar Budha (2)
Affiliation: (1) InSysBio, Moscow, Russia; (2) BeiGene USA, Inc., San Mateo, CA; (3) BeiGene (Beijing) Co., Ltd. Beijing, China; (4) BeiGene (Shanghai) Co., Ltd., Shanghai, China
ASCPT 2022 Annual Meeting, Online
Application of semi-mechanistic mathematical modeling to optimize lymphodepletion regimen administered before infusion of genetically modified T cells
Authors: Oleg Demin Jr (1), Galina Kolesova (1), Antonina Nikitich (1), Ioanna Eleftheriadou (2), Stefan Zajic (2), Ionel Mitrica (3), Alexandra Gyurdieva (2), Lourdes Cucurull-Sanchez (4)
Affiliation: (1) InSysBio, Moscow, Russia; (2) GlaxoSmithKline, Upper Providence, PA, USA; (3) GlaxoSmithKline, Zug, Switzerland; (4) GlaxoSmithKline, Stevenage, Hertfordshire, UK
QSP model of human erythropoiesis under chemotherapy
Authors: Alexander Stepanov, Galina Lebedeva
Tau2022 Global Conference
Application of AD quantitative systems pharmacology model to investigation of therapeutic efficacy of extracellular tau depletion
Authors: Tatiana Karelina
2021
ACoP12 Virtual Conference
HetaSimulator is an Open Source Simulation and Parameter Estimation Software for QSP Modeling
Authors: Ivan Borisov, Evgeny Metelkin
Semi-mechanistic PK/PD modeling of anti-CD47 therapeutic agent
Authors: Elena Vasileva, Oleg Demin Jr
A Quantitative Systems Pharmacology Model of adverse effects of PI3K? inhibitors on intestine inflammation
Authors: Sergey Smirnov 1, Oleg Demin 1, Erqian Yu 2, Xiaomin Song 2, Sri Sahasranaman 2, Yan Ren 2
Affiliation: 1 InSysBio, Moscow, Russia; 2 BeiGene, Beijing, China
Application of CYTOCON DB to compare cell/cytokine profile of patients with melanoma, NSCLC, and healthy subjects
Authors: Vladislav Leonov, Ekaterina Mogilevskaya, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
Investigation of inflammation during Alzheimer's disease by quantitative systems pharmacology model
Authors: Andrey Masliukov, Tatiana Karelina
PBPK modeling of T cell distribution in cancer patients
Authors: Dmitry Shchelokov 1, Oleg Demin Jr 1, Sara Brett 2 , Stefan Zajic 3, Lourdes Cucurull-Sanchez 2
Affiliation: 1 InSysBio, Moscow, Russia; 2 GlaxoSmithKline, Stevenage, Hertfordshire, UK; 3 GlaxoSmithKline, Upper Providence, PA, USA
Development of QSP model of COVID-19 based on Immune Response Template
Authors: Veronika Musatova, Oleg Demin, Maria Kupriyanova, Anna Viktorenko
PBPK/RO modeling of anti-PDL1 antibodies
Authors: Antonina Nikitich, Oleg Demin Jr
Quantitative systems pharmacology model for neurofilament L dynamics in Alzheimer's disease pathology
Authors: Polina Pchelintseva, Tatiana Karelina
The QSP model of amyloid beta and tau oligomers influence on synaptic plasticity
Authors: Stepan Lerner, Tatiana Karelina
Comparison Of Different Approaches To Generate Virtual Patient Populations Of Different Sizes For QSP Model Of Erythropoiesis
Authors: Galina Kolesova, Oleg Demin, Alexander Stepanov
Heta language: Modularity and Reusability in QSP modeling platforms
Authors: Evgeny Metelkin
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