Posters

2022
AACR Annual Meeting 2022, New Orleans, Louisiana, US
Prediction of pharmacokinetics and receptor occupancy of a bispecific antibody against CD40 and PD-L1
Authors: Alexandra Diakonova, Oleg Demin Jr., Dmitry Shchelokov, Oleg Demin
Prediction of intratumoral TIGIT receptor occupancy after the treatment with anti-TIGIT antibodies
Authors: Dmitry Shchelokov (1), Oleg Demin Jr (1), Oleg Demin (1), Ahsan Rizwan (2), Yun Zhang (3), Wei Tan (4), Srikumar Sahasranaman (2), Nageshwar Budha (2)
Affiliation: (1) InSysBio, Moscow, Russia; (2) BeiGene USA, Inc., San Mateo, CA; (3) BeiGene (Beijing) Co., Ltd. Beijing, China; (4) BeiGene (Shanghai) Co., Ltd., Shanghai, China
ASCPT 2022 Annual Meeting, Online
Application of semi-mechanistic mathematical modeling to optimize lymphodepletion regimen administered before infusion of genetically modified T cells
Authors: Oleg Demin Jr (1), Galina Kolesova (1), Antonina Nikitich (1), Ioanna Eleftheriadou (2), Stefan Zajic (2), Ionel Mitrica (3), Alexandra Gyurdieva (2), Lourdes Cucurull-Sanchez (4)
Affiliation: (1) InSysBio, Moscow, Russia; (2) GlaxoSmithKline, Upper Providence, PA, USA; (3) GlaxoSmithKline, Zug, Switzerland; (4) GlaxoSmithKline, Stevenage, Hertfordshire, UK
QSP model of human erythropoiesis under chemotherapy
Authors: Alexander Stepanov, Galina Lebedeva
Tau2022 Global Conference
Application of AD quantitative systems pharmacology model to investigation of therapeutic efficacy of extracellular tau depletion
Authors: Tatiana Karelina
2021
ACoP12 Virtual Conference
HetaSimulator is an Open Source Simulation and Parameter Estimation Software for QSP Modeling
Authors: Ivan Borisov, Evgeny Metelkin
Semi-mechanistic PK/PD modeling of anti-CD47 therapeutic agent
Authors: Elena Vasileva, Oleg Demin Jr
A Quantitative Systems Pharmacology Model of adverse effects of PI3Kδ inhibitors on intestine inflammation
Authors: Sergey Smirnov 1, Oleg Demin 1, Erqian Yu 2, Xiaomin Song 2, Sri Sahasranaman 2, Yan Ren 2
Affiliation: 1 InSysBio, Moscow, Russia; 2 BeiGene, Beijing, China
Application of CYTOCON DB to compare cell/cytokine profile of patients with melanoma, NSCLC, and healthy subjects
Authors: Vladislav Leonov, Ekaterina Mogilevskaya, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
Investigation of inflammation during Alzheimer's disease by quantitative systems pharmacology model
Authors: Andrey Masliukov, Tatiana Karelina
PBPK modeling of T cell distribution in cancer patients
Authors: Dmitry Shchelokov 1, Oleg Demin Jr 1, Sara Brett 2 , Stefan Zajic 3, Lourdes Cucurull-Sanchez 2
Affiliation: 1 InSysBio, Moscow, Russia; 2 GlaxoSmithKline, Stevenage, Hertfordshire, UK; 3 GlaxoSmithKline, Upper Providence, PA, USA
Development of QSP model of COVID-19 based on Immune Response Template
Authors: Veronika Musatova, Oleg Demin, Maria Kupriyanova, Anna Viktorenko
PBPK/RO modeling of anti-PDL1 antibodies
Authors: Antonina Nikitich, Oleg Demin Jr
Quantitative systems pharmacology model for neurofilament L dynamics in Alzheimer's disease pathology
Authors: Polina Pchelintseva, Tatiana Karelina
The QSP model of amyloid beta and tau oligomers influence on synaptic plasticity
Authors: Stepan Lerner, Tatiana Karelina
Comparison Of Different Approaches To Generate Virtual Patient Populations Of Different Sizes For QSP Model Of Erythropoiesis
Authors: Galina Kolesova, Oleg Demin, Alexander Stepanov
Heta language: Modularity and Reusability in QSP modeling platforms
Authors: Evgeny Metelkin
AAPS 2021 PHARMSCI 360, Online
Application of Immune Response Template to Develop QSP Model of COVID-19
Authors: Veronika Musatova, Oleg Demin, Maria Kupriyanova, Anna Viktorenko
ESMO Virtual Congress 2021
Selection of the optimal dose for ALX148, a CD47 blocker, using pharmacokinetic/pharmacodynamic modeling
Authors: Elena Vasileva 1,2, Oleg Demin Jr 2
Affiliation: 1 Lomonosov Moscow State University, Moscow, Russia; 2 InSysBio, Moscow, Russia