2023
14th Annual World Bispecific Summit, Boston, MA
Mechanistic Translational PK/RO Modeling vs MABEL to Predict First-in-Human Dose for Bispecific & Multispecific Antibodies
Authors: Oleg Demin Jr
Speaker: Oleg Demin
PAGE 2023, A Coruna, Spain
An algorithm to generate virtual patients cohort for a model of solid tumor treatment
Authors: Ivan Borisov, Evgeny Metelkin, Galina Kolesova, Oleg Demin
2022
ACoP13, Aurora, Colorado, US
Pharmacokinetics modeling and optimal dose prediction for a bispecific antibody against CD40 and PD1
Authors: Alexandra Diakonova, Oleg Demin Jr, Dmitry Shchelokov, Oleg Demin
The QSP model of microglia role in tau pathology and neurodegeneration
Authors: Stepan Lerner, Maria Myshkina, Tatiana Karelina
Estimation of Imax and IC50 for PD1-PDL1 inhibition of T cell proliferation
Authors: Oleg Demin
Methodological aspects of rate law derivation of cell dynamics processes: focus on QSP model development
Authors: Oleg Demin, Maria Mironovich, Julia Sergienko
Quantitative systems pharmacology modeling of immune response role in Parkinson’s disease
Authors: Tatiana Karelina, Olga Ivanova, Oleg Demin
Quantitative systems pharmacology model for neurofilament L dynamics in multiple sclerosis and under immunomodulatory therapies
Authors: Polina Pchelintseva, Anna Mishina, Tatiana Karelina
Virtual Patients Parallel Simulations in a Hybrid Cloud Environment
Authors: Ivan Borisov, Evgeny Metelkin, Tatiana Karelina, Oleg Demin
ECTRIMS 2022, Amsterdam, the Netherlands and Online
Neurodegeneration quantitative systems pharmacology modeling for analysis of multiple sclerosis therapy
Authors: Polina Pchelintseva (1), Anna Mishina (1), Tatiana Karelina (2)
Affiliation: (1) InSysBio, Moscow, Russia; (2) InSysBio CY, Paphos, Cyprus
AAIC 2022, San Diego, US and Online
Neurofilament L dynamics description in the model of tauopathy
Authors: Polina Pchelintseva
The QSP model of TREM2 influences on inflammatory state of microglia in Alzheimer’s disease
Authors: Stepan Lerner
Application of quantitative systems pharmacology model of Alzheimer’s disease for simulation of efficacy of tyrosine kinase inhibitors
Authors: Tatiana Karelina
PAGE 2022, Ljubljana, Slovenia
Simulation of Rituximab and Natalizumab biomarker efficacy using simplified QSP model of B- and T- lymphocyte dynamics in Multiple Sclerosis
Authors: Anna Mishina (1,2), Tatiana Karelina (1), Evgeny Metelkin (1), Veronika Musatova (1)
Affiliation: (1) InSysBio LLC, Moscow, Russia; (2) Skolkovo Institute of Science and Technology, Moscow, Russia
Parameters Estimation, Identifiability and Predictability Analysis in Systems Biology with HetaSimulator and LikelihoodProfiler
Authors: Ivan Borisov, Evgeny Metelkin
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