AAIC 2022, San Diego, US and Online
Neurofilament L dynamics description in the model of tauopathy
Authors: Polina Pchelintseva
The QSP model of TREM2 influences on inflammatory state of microglia in Alzheimer’s disease
Authors: Stepan Lerner
Application of quantitative systems pharmacology model of Alzheimer’s disease for simulation of efficacy of tyrosine kinase inhibitors
Authors: Tatiana Karelina
PAGE 2022, Ljubljana, Slovenia
Simulation of Rituximab and Natalizumab biomarker efficacy using simplified QSP model of B- and T- lymphocyte dynamics in Multiple Sclerosis
Authors: Anna Mishina (1,2), Tatiana Karelina (1), Evgeny Metelkin (1), Veronika Musatova (1)
Affiliation: (1) InSysBio LLC, Moscow, Russia; (2) Skolkovo Institute of Science and Technology, Moscow, Russia
Parameters Estimation, Identifiability and Predictability Analysis in Systems Biology with HetaSimulator and LikelihoodProfiler
Authors: Ivan Borisov, Evgeny Metelkin
Quantitative Systems Pharmacology for Immuno-Oncology, Cambridgeshire, UK
Specific aspects of the implementation of different combination therapies in the QSP model: focus on the data
Authors: Oleg Demin Jr
QSPC 2022, Leiden, The Netherlands
Heta project
Authors: Evgeny Metelkin
Method to describe multiple effects of regulatory molecules on cell dynamics process in QSP models of immune response
Authors: Oleg Demin, Sergey Smirnov, Galina Lebedeva
Collection of methodological findings for QSP model development
Authors: Oleg Demin, Maria Mironovich, Julia Sergienko
CYTOCON DB as a tool to store and analyze in vivo human concentrations of cells and molecules
Authors: Ekaterina Mogilevskaia, Vladislav Leonov, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
Comparison Of Different Approaches To Generate Virtual Patient Populations Of Different Sizes For QSP Model Of Erythropoiesis
Authors: Galina Kolesova, Oleg Demin, Alexander Stepanov
Confidence Intervals by Constrained Optimization – a Single Algorithm for Identifiability and Predictability Analysis in Systems Biology
Authors: Ivan Borosov, Evgeny Metelkin
QSP model that describes neurofilament L protein dynamics in Alzheimer’s disease
Authors: Polina Pchelintseva, Tatiana Karelina, Oleg Demin
Application of Immune Response Template (IRT) to the COVID19 QSP platform prototype development
Authors: Veronika Musatova, Oleg Demin, Anna Viktorenko, Anastasia Ivanova
Stimulation of erythropoiesis with ESA or blood donation: QSP model
Authors: Alexander Stepanov, Galina Lebedeva
QSP Modeling of Thrombopoiesis and Essential Thrombocythemia Treatment
Authors: Svetlana Rubina (1), Artem Ivanov (2), Galina Lebedeva (1)
Affiliation: (1) InSysBio, Moscow, Russia, (2) Lomonosov Moscow State University, Moscow, Russia
Dynamic and reproducible reports for QSP modeling in R and Julia: working examples
Authors: Evgeny Metelkin, Ivan Borisov
fIVE Database is a repository of in vitro data and estimates of kinetic parameters for systems modeling
Authors: Alexander Stepanov, Veronika Musatova, Anna Victorenko, Ekaterina Goryacheva, Nail Gizzatkulov, Oleg Demin
QSP model of human granulopoiesis and neutrophil homeostasis under growth factor, stem-cell mobilizing and cytotoxic therapies
Authors: Galina Lebedeva, Alexander Stepanov
Exploration of potential efficacy of tau-targeting immunotherapy and simulation of combination of immunotherapies targeting tau and amyloid using QSP approach
Authors: Tatiana Karelina, Polina Pchelintseva, Oleg Demin
Prediction of pharmacokinetics and optimal dose for a bispecific antibody against CD40 and PD1
Authors: Alexandra Diakonova, Oleg Demin Jr, Dmitry Shchelokov, Oleg Demin
AACR Annual Meeting 2022, New Orleans, Louisiana, US
Prediction of pharmacokinetics and receptor occupancy of a bispecific antibody against CD40 and PD-L1
Authors: Alexandra Diakonova, Oleg Demin Jr., Dmitry Shchelokov, Oleg Demin
Prediction of intratumoral TIGIT receptor occupancy after the treatment with anti-TIGIT antibodies
Authors: Dmitry Shchelokov (1), Oleg Demin Jr (1), Oleg Demin (1), Ahsan Rizwan (2), Yun Zhang (3), Wei Tan (4), Srikumar Sahasranaman (2), Nageshwar Budha (2)
Affiliation: (1) InSysBio, Moscow, Russia; (2) BeiGene USA, Inc., San Mateo, CA; (3) BeiGene (Beijing) Co., Ltd. Beijing, China; (4) BeiGene (Shanghai) Co., Ltd., Shanghai, China
ASCPT 2022 Annual Meeting, Online
Application of semi-mechanistic mathematical modeling to optimize lymphodepletion regimen administered before infusion of genetically modified T cells
Authors: Oleg Demin Jr (1), Galina Kolesova (1), Antonina Nikitich (1), Ioanna Eleftheriadou (2), Stefan Zajic (2), Ionel Mitrica (3), Alexandra Gyurdieva (2), Lourdes Cucurull-Sanchez (4)
Affiliation: (1) InSysBio, Moscow, Russia; (2) GlaxoSmithKline, Upper Providence, PA, USA; (3) GlaxoSmithKline, Zug, Switzerland; (4) GlaxoSmithKline, Stevenage, Hertfordshire, UK
QSP model of human erythropoiesis under chemotherapy
Authors: Alexander Stepanov, Galina Lebedeva