2022
ACoP13, Aurora, Colorado, US
Pharmacokinetics modeling and optimal dose prediction for a bispecific antibody against CD40 and PD1
Authors: Alexandra Diakonova, Oleg Demin Jr, Dmitry Shchelokov, Oleg Demin
The QSP model of microglia role in tau pathology and neurodegeneration
Authors: Stepan Lerner, Maria Myshkina, Tatiana Karelina
Estimation of Imax and IC50 for PD1-PDL1 inhibition of T cell proliferation
Authors: Oleg Demin
Methodological aspects of rate law derivation of cell dynamics processes: focus on QSP model development
Authors: Oleg Demin, Maria Mironovich, Julia Sergienko
Quantitative systems pharmacology modeling of immune response role in Parkinson’s disease
Authors: Tatiana Karelina, Olga Ivanova, Oleg Demin
Quantitative systems pharmacology model for neurofilament L dynamics in multiple sclerosis and under immunomodulatory therapies
Authors: Polina Pchelintseva, Anna Mishina, Tatiana Karelina
Virtual Patients Parallel Simulations in a Hybrid Cloud Environment
Authors: Ivan Borisov, Evgeny Metelkin, Tatiana Karelina, Oleg Demin
ECTRIMS 2022, Amsterdam, the Netherlands and Online
Neurodegeneration quantitative systems pharmacology modeling for analysis of multiple sclerosis therapy
Authors: Polina Pchelintseva (1), Anna Mishina (1), Tatiana Karelina (2)
Affiliation: (1) InSysBio, Moscow, Russia; (2) InSysBio CY, Paphos, Cyprus
AAIC 2022, San Diego, US and Online
Neurofilament L dynamics description in the model of tauopathy
Authors: Polina Pchelintseva
The QSP model of TREM2 influences on inflammatory state of microglia in Alzheimer’s disease
Authors: Stepan Lerner
Application of quantitative systems pharmacology model of Alzheimer’s disease for simulation of efficacy of tyrosine kinase inhibitors
Authors: Tatiana Karelina
PAGE 2022, Ljubljana, Slovenia
Simulation of Rituximab and Natalizumab biomarker efficacy using simplified QSP model of B- and T- lymphocyte dynamics in Multiple Sclerosis
Authors: Anna Mishina (1,2), Tatiana Karelina (1), Evgeny Metelkin (1), Veronika Musatova (1)
Affiliation: (1) InSysBio LLC, Moscow, Russia; (2) Skolkovo Institute of Science and Technology, Moscow, Russia
Parameters Estimation, Identifiability and Predictability Analysis in Systems Biology with HetaSimulator and LikelihoodProfiler
Authors: Ivan Borisov, Evgeny Metelkin
Quantitative Systems Pharmacology for Immuno-Oncology, Cambridgeshire, UK
Specific aspects of the implementation of different combination therapies in the QSP model: focus on the data
Authors: Oleg Demin Jr
QSPC 2022, Leiden, The Netherlands
Heta project
Authors: Evgeny Metelkin
Method to describe multiple effects of regulatory molecules on cell dynamics process in QSP models of immune response
Authors: Oleg Demin, Sergey Smirnov, Galina Lebedeva
Collection of methodological findings for QSP model development
Authors: Oleg Demin, Maria Mironovich, Julia Sergienko
CYTOCON DB as a tool to store and analyze in vivo human concentrations of cells and molecules
Authors: Ekaterina Mogilevskaia, Vladislav Leonov, Elita Gerasimuk, Nikolay Pervushin, Nail Gizzatkulov, Oleg Demin
Comparison Of Different Approaches To Generate Virtual Patient Populations Of Different Sizes For QSP Model Of Erythropoiesis
Authors: Galina Kolesova, Oleg Demin, Alexander Stepanov
Confidence Intervals by Constrained Optimization – a Single Algorithm for Identifiability and Predictability Analysis in Systems Biology
Authors: Ivan Borosov, Evgeny Metelkin
QSP model that describes neurofilament L protein dynamics in Alzheimer’s disease
Authors: Polina Pchelintseva, Tatiana Karelina, Oleg Demin
Application of Immune Response Template (IRT) to the COVID19 QSP platform prototype development
Authors: Veronika Musatova, Oleg Demin, Anna Viktorenko, Anastasia Ivanova
Stimulation of erythropoiesis with ESA or blood donation: QSP model
Authors: Alexander Stepanov, Galina Lebedeva
QSP Modeling of Thrombopoiesis and Essential Thrombocythemia Treatment
Authors: Svetlana Rubina (1), Artem Ivanov (2), Galina Lebedeva (1)
Affiliation: (1) InSysBio, Moscow, Russia, (2) Lomonosov Moscow State University, Moscow, Russia
Dynamic and reproducible reports for QSP modeling in R and Julia: working examples
Authors: Evgeny Metelkin, Ivan Borisov
fIVE Database is a repository of in vitro data and estimates of kinetic parameters for systems modeling
Authors: Alexander Stepanov, Veronika Musatova, Anna Victorenko, Ekaterina Goryacheva, Nail Gizzatkulov, Oleg Demin
QSP model of human granulopoiesis and neutrophil homeostasis under growth factor, stem-cell mobilizing and cytotoxic therapies
Authors: Galina Lebedeva, Alexander Stepanov
Exploration of potential efficacy of tau-targeting immunotherapy and simulation of combination of immunotherapies targeting tau and amyloid using QSP approach
Authors: Tatiana Karelina, Polina Pchelintseva, Oleg Demin
Prediction of pharmacokinetics and optimal dose for a bispecific antibody against CD40 and PD1
Authors: Alexandra Diakonova, Oleg Demin Jr, Dmitry Shchelokov, Oleg Demin
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