InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, releases a new version of LikelihoodProfiler.jl. LikelihoodProfiler represents a unified Julia package that can be used for practical identifiability analysis for complex computationally demanding QSP models.
Initially, LikelihoodProfiler.jl included a method (CICO) for estimating confidence intervals (CI) and assessing the practical identifiability of model parameters using the profile likelihood approach. Now LikelihoodProfiler package provides various state-of-the-art methods for profile likelihood analysis, including optimization-based and integration-based profiles, CI endpoints search, and more. These methods are now unified under a new interface, making it easier for users to switch between them. The results of LikelihoodProfiler.jl analysis can be used to further reduce the complexity and eliminate model’s uncertainty by implementing identifiable parametrizations and model reduction techniques.
Ivan Borisov, Senior Software Developer, comments on the new version of LikelihoodProfiler.jl, “This release marks the first version of the revamped package. We plan to introduce additional methods, improve interfaces, enhance documentation, and more to make the package more valuable to the community.”
LikelihoodProfiler package is open-source and freely available on GitHub: https://github.com/insysbio/LikelihoodProfiler.jl
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s cutting-edge QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry and innovative biotech companies. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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03 Mar 2020 12:25
13th InSysBio Annual Internal Scientific Meeting
26-28 February 2020 InSysBio QSP-company held its 13th Annual Internal Scientific Meeting. InSysBio team presented the results of 2019 year professional progress. Every member demonstrated their personal achievements and shared the plans for the future development. Oleg Demin, InSysBio CEO and founder, summarized all the company’s advancement of the year 2019.
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10 Mar 2020 12:48
InSysBio to share the news from QSPC2020 management
Today we have received the concerning news from QSPC2020 organizers about the cancellation of the conference in response to COVID-19 outbreak continuation. Quantitative Systems Pharmacology Conference 2020 was planned to be held in April 22-24, 2020 Leiden, The Netherlands. InSysBio team was prepared to present 10 posters
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