InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, releases a new version of LikelihoodProfiler.jl. LikelihoodProfiler represents a unified Julia package that can be used for practical identifiability analysis for complex computationally demanding QSP models.
Initially, LikelihoodProfiler.jl included a method (CICO) for estimating confidence intervals (CI) and assessing the practical identifiability of model parameters using the profile likelihood approach. Now LikelihoodProfiler package provides various state-of-the-art methods for profile likelihood analysis, including optimization-based and integration-based profiles, CI endpoints search, and more. These methods are now unified under a new interface, making it easier for users to switch between them. The results of LikelihoodProfiler.jl analysis can be used to further reduce the complexity and eliminate model’s uncertainty by implementing identifiable parametrizations and model reduction techniques.
Ivan Borisov, Senior Software Developer, comments on the new version of LikelihoodProfiler.jl, “This release marks the first version of the revamped package. We plan to introduce additional methods, improve interfaces, enhance documentation, and more to make the package more valuable to the community.”
LikelihoodProfiler package is open-source and freely available on GitHub: https://github.com/insysbio/LikelihoodProfiler.jl
About InSysBio
InSysBio is a group of Quantitative Systems Pharmacology (QSP) companies located in Limassol, Cyprus (INSYSBIO CY Ltd) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s cutting-edge QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry and innovative biotech companies. For more information about InSysBio, its solutions and services, visit www.insysbio.com
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04 Mar 2019 15:40
12th InSysBio Annual Internal Scientific Meeting
20-22 February 2019 InSysBio company held the 12th Annual Internal Scientific Meeting. Results of the last year and plans for the ongoing year were discussed.
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13 Mar 2019 15:50
Tatiana Karelina on TV
Tatiana Karelina, Head of the Alzheimer’s Disease modeling group at InSysBio participated in the Russian TV show «Us and science. Science and us».
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22 Mar 2019 14:58
InSysBio to present at AACR Annual Meeting 2019
InSysBio announces their participation at American Association for Cancer Research Annual Meeting 2019 being held on March 29 – April 3 in Atlanta, GA
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26 Mar 2019 19:51
InSysBio to present at PEGS Boston
InSysBio announces their participation at 15th Essential Protein Engineering Summit being held on April 8-12 in Boston, MA.
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