InSysBio team to publish the new article in Journal of Pharmacokinetics and Pharmacodynamics

NEWS
Publication
July 11, 2022

July 11, 2022

The new article "Application of different approaches to generate virtual patient populations for the quantitative systems pharmacology model of erythropoiesis" by Galina Kolesova, Alexander Stepanov, Galina Lebedeva and Oleg Demin has been published in Journal of Pharmacokinetics and Pharmacodynamics. 

Galina Kolesova comments on the article, "The traditional approach of QSP modeling includes fitting a model output to a series of mean data values.  As a result, the parameters of the model represent fixed numbers enabling the description of mean data, thus we generated the so-called “reference patient”. However, the results of clinical trials include a description of variability in patients’ responses to a drug, which is typically expressed in terms of conventional statistical parameters such as standard deviations (SDs) from mean values. To allow a QSP model to reproduce the variability observed in response to a drug administration, a virtual patient (VP) population is usually generated and applied. In our study, we propose and compare four different approaches to generate virtual patient populations based on experimentally measured mean data and statistics, namely, (1) Monte Carlo Markov chain (MCMC), (2) model fitting to Monte Carlo samples, (3) population of clones, and (4) stochastically bounded selection. We applied these approaches to generate virtual patient populations in the QSP model of erythropoiesis. Our main task was to create a sample of virtual patients of the same size as that in clinical trials".

About InSysBio

InSysBio is a Quantitative Systems Pharmacology (QSP) company located in Edinburgh, UK (INSYSBIO UK LIMITED), Moscow, Russia (INSYSBIO LLC) and Cyprus (INSYSBIO CY Ltd). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com.

 

March 2024
MoTuWeThFrSaSu
    
1
2
3
4
5
6
1. 06 Mar 2024 12:40 InSysBio to present posters at ASCPT 2024 Annual Meeting InSysBio announces its participation in the ASCPT 2024 Annual Meeting which is to be held March 27-29, at the Broadmoor in Colorado Springs, CO. Tatiana Karelina, Head of Neurodegenerative Diseases modeling team, and Vladislav Leonov, CYTOCON DB team, will present 4 posters by InSysBio
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
Upcoming Events
Tags
Latest News
22.02
14th InSysBio’s Annual Internal Scientific Meeting
24.01
InSysBio to present the new Plugin for Sublime Text and Heta compiler Online
07.12
InSysBio to release public beta of fIVE Calculator
06.04
InSysBio to release Immune Response Template 3.6.2 for QSP modeling
16.01
InSysBio team to publish the new article “Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study”