February 21, 2020
IRT Version 3.0.0 acquires a wide variety of updates and new options
(Moscow – 21.02.2020) InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) platform development and provision, moves forward to the future. According to InSysBio Top Officials, the report on the latest amendments within the IRT was yesterday presented at the company’s internal seminar. Veronika Musatova, Head of IRT development team, highlights, “The new version is mainly aimed to boost and facilitate the development of QSP models in immunology and immuno-oncology therapeutic areas. Previously IRT was mainly addressed to as a kind of manual on immune cell interactions and regulations rather than fully-fledged database and now it is rethought to be an efficient and useful tool”.
Actually, new schemes and players were added into the database, total revision of core model reactions and parameters was introduced. Moreover, a great variety of new cell types and regulatory molecules has become represented. One of the advantages of the IRT is implementation of a method allowing to translate in vitro measured EC50/IC50 of regulatory cytokine effects into in vivo model. Due to QSP modeling technologies drug development acquires dramatic efficiency increase. Globally the QSP modeling assists to determine the optimal doses, target groups of patients and substances effect on the human body. These advantages of QSP modeling are enabled by the fact that mathematical models represent virtual constructions based on experimental data and real objects’ features. Application of IRT allows to simplify routine work on QSP model development and calibration by using calibrated sub-models exported from IRT as building blocks.
In comparison with the previous versions of IRT the latest one provides higher quantity of identified parameters, namely about 60% of them have been identified. Particularly, schemes and equations according to introduced cell types have been revised. New regulatory molecules are added in descriptions of cells proliferation, apoptosis, migration and activation.
Veronika Musatova outlines, “Our further soft development is underway, for instance cytokines sources profiles and new models are expected to appear. Some outdated information is being actualized”.
About InSysBio:
InSysBio is a Quantitative Systems Pharmacology (QSP) company located in Moscow, Russia (INSYSBIO LLC) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com.
For more information about IRT Version 3.0.0, please visit irt.insysbio.com.
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02 Jun 2020 13:24
InSysBio to announce the launch of QSP model of COVID-19
The new open source project to be developed and updated Online
InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, announces the launch of its fundamentally new project in response to the ongoing global threat, the open source QSP model of COVID-19. In accordance with its mission, which is to assist pharmaceutical industry to speed up the delivery of the cure to patients, InSysBio team could not stay aside. Thus, the aim of the new project is to develop QSP model of COVID-19 describing virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.
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05 Jun 2020 15:04
InSysBio to present IRT Navigator 3
InSysBio presents IRT Navigator 3 which is an application software providing intuitive interface to work with the Immune Response Template Database in accordance with the user’s needs. It supplies the navigation within the schemes and components and efficient development of QSP models based on IRT Database.
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08 Jun 2020 15:30
InSysBio to perform the first step in development of COVID-19 QSP model
InSysBio has performed the first step in the direction of development of QSP model of COVID-19 describing virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.
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12 Jun 2020 16:45
InSysBio to release the new version of Cytocon DB 1.1.6.4
We are glad to announce the release of the new version of Cytocon DB 1.1.6.4. The DB was significantly extended with new data due to well-coordinated workflow of Cytocon DB team and its new members. Namely, 54 diseases, 24 tissues, 42 molecules, 24 cells and 3701 concentrations were introduced.
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17 Jun 2020 15:48
InSysBio to welcome its new team member Dr. Neil Benson
InSysBio announces the appointment of Dr. Neil Benson as Principal Consultant in area of business development
(Edinburgh-Moscow-16.06.2020) InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) modeling, is proud to announce its new team member Dr. Neil Benson! Dr. Benson has joined InSysBio as Principal Consultant in area of business development of both INSYSBIO LLC and INSYSBIO UK LIMITED. In his capacity as Principal Consultant to InSysBio, he will support further development of the outstanding IO and AD QSP offering of the company.
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22 Jun 2020 17:04
InSysBio team posters to be presented at AACR Virtual Annual Meeting II
AACR Virtual Annual Meeting II has begun! American Association for Cancer Research Annual Meeting is held virtually this year on June 22-24 due to COVID-19 spread. Today InSysBio team's posters were published on AACR website
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30 Jun 2020 15:45
InSysBio to present COVID-19 QSP model further development
InSysBio continues to move forward in COVID-19 QSP model development. Its aim is to describe virus and host cell life cycles, innate and adoptive immune response and possible therapeutic treatments.
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