InSysBio presents an enhanced version of its Immune Response Template Database

NEWS
Press-Release
February 21, 2020

February 21, 2020

IRT Version 3.0.0 acquires a wide variety of updates and new options

(Moscow – 21.02.2020) InSysBio, one of the world’s pioneers of Quantitative Systems Pharmacology (QSP) platform development and provision, moves forward to the future. According to InSysBio Top Officials, the report on the latest amendments within the IRT was yesterday presented at the company’s internal seminar. Veronika Musatova, Head of IRT development team, highlights, “The new version is mainly aimed to boost and facilitate the development of QSP models in immunology and immuno-oncology therapeutic areas. Previously IRT was mainly addressed to as a kind of manual on immune cell interactions and regulations rather than fully-fledged database and now it is rethought to be an efficient and useful tool”.

Actually, new schemes and players were added into the database, total revision of core model reactions and parameters was introduced. Moreover, a great variety of new cell types and regulatory molecules has become represented. One of the advantages of the IRT is implementation of a method allowing to translate in vitro measured EC50/IC50 of regulatory cytokine effects into in vivo model. Due to QSP modeling technologies drug development acquires dramatic efficiency increase. Globally the QSP modeling assists to determine the optimal doses, target groups of patients and substances effect on the human body. These advantages of QSP modeling are enabled by the fact that mathematical models represent virtual constructions based on experimental data and real objects’ features. Application of IRT allows to simplify routine work on QSP model development and calibration by using calibrated sub-models exported from IRT as building blocks.

In comparison with the previous versions of IRT the latest one provides higher quantity of identified parameters, namely about 60% of them have been identified. Particularly, schemes and equations according to introduced cell types have been revised. New regulatory molecules are added in descriptions of cells proliferation, apoptosis, migration and activation.
Veronika Musatova outlines, “Our further soft development is underway, for instance cytokines sources profiles and new models are expected to appear. Some outdated information is being actualized”.

About InSysBio:

InSysBio is a Quantitative Systems Pharmacology (QSP) company located in Moscow, Russia (INSYSBIO LLC) and Edinburgh, UK (INSYSBIO UK LIMITED). InSysBio was founded in 2004 and has an extensive track record of helping pharmaceutical companies to make right decisions on the critical stages of drug research and development by application of QSP modeling. InSysBio’s innovative QSP approach has already become a part of the drug development process implemented by our strategic partners: there are more than 100 completed projects in collaboration with leaders of pharmaceutical industry. For more information about InSysBio, its solutions and services, visit www.insysbio.com.

For more information about IRT Version 3.0.0, please visit irt.insysbio.com.

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1. 14 Dec 2022 14:39 IRT Onco version is focused on tumor-specific immune response InSysBio launches the Oncology version of Immune Response Template (IRT). IRT in Oncology represents a QSP platform of immune system in cancer, simultaneously being a tool for development of QSP and mechanistic models related to tumor-specific immune response.
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