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Selected posters and presentations

ACoP9, San Diego, CA, US

  • Poster: Quantitative Systems Pharmacology (QSP) model of bispecific T-Cell engaging antibody constructs for Acute Myeloid Leukemia treatment
    Authors: Oleg Demin Jr1, Svetlana Rubina1, Theresa Yuraszeck2, Khamir Mehta2, Vaishali Chudasama2, Matthias Klinger3, Cedric Dos Santos2, Oleg Demin1, Sergey Ermakov2
    Affiliation: 1InSysBio, Moscow, Russia, 2Amgen Inc., Thousand Oaks, CA, USA,3Amgen Research (Munich), Germany
  • Poster: Translational quantitative systems pharmacology model of tau pathology in human and mouse for immunotherapy investigation
    Authors: Tatiana Karelina and Alexander Stepanov
  • Poster: Identification of parameters of QSP models responsible for observed variability in experimental data
    Authors: Galina Kolesova and Oleg Demin
  • Presentation: Quantitative systems pharmacology model for amyloid pathology investigation Speaker: Tatiana Karelina

AAIC 2018, Chicago, IL, US

  • Poster: Translational quantitative systems pharmacology model of tauopathies
    Authors: Tatiana Karelina and Alexander Stepanov
  • Poster: Description of different amyloid toxic species and pathology progression by mechanistic quantitative systems pharmacology model
    Authors: Tatiana Karelina, Alexander Stepanov and Alena Zhukova

PAGE 2018, Montreux, Switzerland

  • Poster: A semi-mechanistic model of targeted therapy for melanoma
    Authors: Dmitrii Shchelokov and Oleg Demin Jr
  • Poster: Simulations of tau-targeted therapies using quantitative systems pharmacology model of tau pathology
    Authors: Tatiana Karelina, Alexander Stepanov and Oleg Demin
  • Poster: Quantitative Systems Pharmacology Modeling of CAR-T Therapy and T Cell Engaging Bispecific Antibodies: B-cell Acute Lymphoblastic Leukemia Case Study
    Authors: Oleg Demin Jr and Antonina Nikitich
  • Poster: Immune Response Template for Quantitative Systems Pharmacology Modeling: Description of Co-inhibitory and Co-stimulatory Receptors Interaction
    Authors: Antonina Nikitich and Oleg Demin Jr
  • Poster: Modeling of amyloid accumulation in subjects at risk of Alzheimer’s disease under BACE inhibition treatment
    Authors: Etienne Pigeolet1, Konstantinos Biliouris2, Ulf Neumann3, Alexandra Urusova4, Oleg Demin4 and Tatiana Karelina4
    Affiliation: 1Novartis Pharma AG, Basel, Switzerland; 2Novartis Institute for Biomedical Research, Cambridge, USA; 3Novartis Institute for Biomedical Research, Basel, Switzerland; 4InSysBio, Moscow, Russia

ASCPT 2018, Orlando, FL, US

  • Poster: PBPK modeling for therapeutic nanoparticles loaded with drug: distribution and release
    Authors: Evgeny Metelkin and Oleg Demin
  • Poster: Translational QSP model of amyloid beta allows to predict both short and long term response of AD patients to different therapies
    Authors: Tatiana Karelina1, Oleg Demin1, Oleg Demin Jr1, Timothy Nicholas2
    Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer global R&D, Groton, CT, USA
  • Poster: Multiple myeloma quantitative systems pharmacology model: development and usage for pomalidomide influence evaluation
    Authors: Svetlana Rubina, Oleg Demin and Oleg Demin Jr

AAT-AD/PD Focus Meeting 2018, Torino, Italy

  • Presentation: In silico implementation of tauopathy transgenic mouse model
    Speaker: Alexander Stepanov

ACoP8, Fort Lauderdale, Florida, US

  • Mechanistic model for the role of the microgliall cells in amyloid accumulation and its modulation by immunotherapy
    Authors: T. Karelina, A. Stepanov, T. Yuraszeck, S Wood
    Poster
  • Tau propagation system pharmacology model based on three-component memory-retrieval system predicts heterogeneous response to immunotherapy in brain regions
    Authors: T. Karelina, A. Stepanov, T. Nicholas
    Poster
  • Development of systems pharmacology model of multiple myeloma
    Authors: S. Rubina, O. Demin Jr., O. Demin
    Poster
  • Mechanistic modeling of natural killer cell dynamics and cytokine production to support systems pharmacology modeling of the immune response
    Authors: O. Demin, M. Benkov, O. Demin Jr.
    Poster
  • A quantitative systems pharmacology model of asthma
    Authors: S. Smirnov, G.Lebedeva, O. Demin, T. Petukhova, L. Cucurull-Sanchez, D. Fairman
    Poster
  • Model-based analysis of clinical assays for assessing the efficacy of vaccines against Respiratory Syncytial Virus (RSV)
    Authors: G.Lebedeva, N. Pakhomov, O. Demin Jr., O.Demin
    Poster
  • Systems pharmacology modeling for optimization of targeted therapy for melanoma
    Authors: D. Shchelokov, O. Demin Jr.
    Poster
  • Mechanistic modeling of co-stimulatory and co-inhibitory surface molecules effect on cell-cell interactions
    Authors: O. Demin Jr.
    Poster
  • Poster: Quantitative systems pharmacology modeling to evaluate and prioritize targets (CD19, CD20, CD22) for bispecific antibodies and CAR-T in acute lymphoblastic leukemia
    Authors: Oleg Demin Jr and Antonina Nikitich
  • Poster: Evaluation of Potential Low-Dose Regimens of Oral Fixed-Dose Combination of Cytidine Deaminase Inhibitor E7727 with Decitabine (ASTX727-LD) to Minimize Decitabine-Mediated Neutropenia in Low-Risk MDS Subjects Using Systems Pharmacology Modeling
    Authors: Antonina Nikitich1, Oleg Demin1, Oleg Demin Jr1, Aram Oganesian2
    Affiliation: 1InSysBio, Moscow, Russia; 2Astex Pharmaceuticals Inc., Pleasanton, CA, USA

7th German-Russian Week of the Young Researcher, Moscow, Russia

  • SbmlViewer is a visualization tool for systems biology modeling
    Authors: V. Tkachenko, E. Metelkin
    Poster, RG

MCCMB'17 Moscow, Russia

  • Mathematical model of multisite Tau protein phosphorylation for prediction of sensitivity to therapeutic interventions.
    Authors: A. Stepanov, T. Karelina, O. Demin, N. Markevich, T. Nicholas, S. Duvvuri.
    Poster

ADPD2017 Vienna, Austria

  • Amyloid toxicity and different mechanisms of action for amyloid-targeted treatments studied by quantitative systems pharmacology model.
    Authors: T. Karelina, T. Nicholas
    Poster

ASCPT2017 Washington, DC, US

  • Chemokine mediated cell migration.
    Authors: O. Demin, E. Metelkin
    Poster PII-032
  • Effect of costimulatory and co-inhibitory surface molecules on processes associated with cell-to-cell interactions.
    Authors: O. Demin Jr, E. Metelkin, O. Demin
    Poster PII-034
  • Cytokine production by immune cells.
    Authors: O. Demin Jr, E. Metelkin, O. Demin
    Poster PII-035
  • Mechanistic model of mast cell life cycle, activation and release of bioactive molecules designed to support systems pharmacology modeling of the immune response.
    Authors: G. Lebedeva, S. Smirnov, E.Metelkin, O. Demin
    Poster PII-072
  • Mechanistic model of neutrophil cell dynamics and activation to inform systems pharmacology modeling of the immune response.
    Authors: G. Lebedeva, S. Smirnov, E. Metelkin, O. Demin
    Poster PII-073
  • Neutrophils survival in the presence of pro-inflammatory cytokines.
    Authors: E. Metelkin, A.Uvarovskii, O. Demin
    Poster PII-097
  • Mathematical description of multiple effects of regulatory molecules.
    Authors: S. Smirnov, E. Metelkin, G. Lebedeva, O. Demin
    Poster PII-131

Promo booklets

InSysBio presents a list of case studies on systems pharmacology modeling for drug development. ISB case studies 2016 booklet A4 online.pdf Лицензия Creative Commons
The second series of case studies on systems pharmacology modeling for drug development by InSysBio. ISB case studies II 2016 booklet A4 online.pdf Лицензия Creative Commons
InSysBio presents Immune Responce Template. IRT 1.0 2016 booklet A5 online.pdf Лицензия Creative Commons

ACoP 2016, Bellevue, Washington, US

 

  • Prediction of treatment efficacy of direct antiviral agent combinations in chronic hepatitis C patients using quantitative systems pharmacology modeling approach.
    Subject: HCV, antiviral, drug combinations
    Author: Demin O. Jr
    Poster
  • Quantitative systems pharmacology model of amyloid pathology allows for clinical endpoint prediction and hypothesis testing
    Subject: amyloid pathology,
    Authors: Karelina T., Demin O., Duvvuri S., Nicholas T.
    Poster
  • Mechanistic approach to describe multiple effects of regulatory molecules on cell dynamics process in immune response.
    Subject: modeling techniques, immune response
    Authors: Demin O., Lebedeva G., Smirnov S.
    Presentation, Poster
  • Exploration of differences between mechanism-based PK/PD and systems pharmacology models.
    Subject: modeling, review
    Author: Demin O.
    Poster
  • Modeling of immune response suppression by hepatitis C virus and nivolumab treatement in chronic hepatitis C patients using quantitative systems pharmacology approach.
    Subject: HCV, antiviral, immune response
    Author: Demin O. Jr
    Poster
  • Immune Response Template for Quantitative Systems Pharmacology Modeling of Immunotherapy in Oncology.
    Subject: immune response, database
    Author: Demin O. Jr, Nikitich A.
    Poster

PAGE 2016, Lisboa, Portugal

 

  • Development of Immune Response Template for Systems Pharmacology Modeling of Immunotherapy in Oncology.
    Subject: immunooncology, database
    Authors: Metelkin E., Demin O. Jr, Nikitich A., Demin O.
    Poster
  • Clinical trial simulation and hypothesis testing using amyloid pathology longitudinal translational model.
    Subject: Alzheimer
    Authors: Karelina T., Demin O., Duvvuri S., Nicholas T.
    Poster
  • Population PK modeling of RPH-104, novel optimized IL-1 beta trap, and assessment of the immunogenicity effect on pharmacokinetics.
    Subject: population modeling, Behcet, FMF
    Authors: Metelkin E., Petukhova T., Demin O., Shipaeva E., Samsonov M., Krotkova A., Lavrovsky Y.
    Poster

ASCPT 2016 Annual Meeting, San Diego, USA

 

  • Analysis of brain pharmacodynamics of gamma-secretase inhibitors using quantitative translational systems pharmacology model
    Subject: Alzheimer
    Authors: Karelina T., Demin O., Nicholas T., Duvvuri S.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Implementation Of Immune Response Suppression By Hepatitis C Virus
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Population modeling study for evaluation of effective and safe dose of RPH-104 for the treatment of Behcet’s syndrome and FMF.
    Subject: population modeling, Behcet, FMF
    Authors: Metelkin E., Petukhova T., Demin O., Shipaeva E., Samsonov M., Krotkova A., Lavrovsky Y.
    Poster
  • Simulation of longitudinal tau species behavior during different therapies using quantitative systems pharmacology model
    Subject: Alzheimer
    Authors: Karelina T., Demin O., Stepanov A., Markevich N., Sintsov A., Nicholas T., Duvvuri S.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Implementation Of Immune Response Suppression By Hepatitis C Virus
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Exploration Of Effect Of Combinations Of Direct Antiviral Agents On HCV Production During Treatment Of HCV Patients
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Systems Pharmacology Model Of Hepatitis C: Prediction Of Results Of Ongoing Clinical Trials Of Direct Antiviral Agents Combination Therapies
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster
  • Population modeling and simulation of RPH-203 effects in the context of prevention of skeletal-related events in patients with bone metastases
    Subject: oncology, population modeling, metastases
    Authors: Metelkin E., Petukhova T., Demin O., Archuadze S., Konopleva G., Koloda D., Samsonov M.
    Poster
  • Development Of Immune Response Template For Systems Pharmacology Modelling Of Immunotherapy In Oncology
    Subject: immunooncology, database
    Authors: Demin O. Jr, Nikitich A., Demin O.
    Poster
  • Prediction Of Sofosbuvir Active Compound Dynamics In Human Liver In Vivo During Treatment
    Subject: hepatitis C
    Authors: Demin O. Jr, Demin O.
    Poster

EMBL-EBI Industry Systems Pharmacology Workshop 2014, Cambridge, UK.

 

  • Systems pharmacology modeling in drug research and development: application of modeling technique.
    Subject: methodology
    Author: Demin O.
    Presentation

Systems Pharmacology in Drug Discovery & Development 2014, Noordwijkerhout, The Netherlands.

 

  • Systems pharmacology model of amyloid pathology predicts different rates of progression to the same median state for the different patient populations
    Subject: gout
    Authors: Karelina T., Duvvuri S., Nicholas T., Demin O.
    Poster, Abstract
  • A systems pharmacology model of purine metabolism to explore novel options for the treatment of Gout
    Subject: Alzheimer, amyloid
    Authors: Dua ., Demin O.Jr., Sokolov V., Yakovleva T., Demin O., Van der Graaf P.
    Poster

ASCPT Annual Meeting 2014, Atlanta, USA

 

  • Systems Pharmacology Modeling of Calcium and Phosphate Metabolism in Chronic Kidney Disease
    Subject: CKD-MBD
    Authors: Bakhmutova A., Demin O. Jr., Demin O.
    Poster
  • Investigation of Dapagliflozin Inhibition Effect on Glucose Reabsorption Using Systems Pharmacology Approach
    Subject: SGLT2 inhibitors, diabetes
    Authors: Yakovleva T., Demin O. Jr., Demin O.
    Poster
  • Development and Application of Systems Pharmacology Model to Predict Nausea Resulted from Administration GLP-1 Agonists
    Subject: GLP1 agonists, nausea
    Authors: Voroniva V., Demin O. Jr., Demin O.
    Poster

American Conference on Pharmacometrics (ACoP) 2013, Fort Lauderdale, USA

 

  • Development of a Human System Pharmacology Model to Characterize Diabetic Nephropathy Disease Progression and the Effect of Standard of Care Therapy
    Subject: diabetic nephropathy
    Authors: Chen D., Voronova V., Smirnov S., Metelkin E., Goryacheva E., Bahmutova A., Demin O.
    Poster

ASCPT 2013 Annual Meeting, Indianapolis, USA

 

  • Systems Pharmacology Modeling in Research and Development
    Subject: Zeliuton, Celiac disease
    Author: Demin O.
    Presentation
  • Exploration of molecular mechanisms underlying susceptibility of HCV patients to IFN-? therapy via systems pharmacology modeling
    Subject: HCV
    Authors: Smirnov S., Benson N., Van Der Graaf PH., Flores V., Goryacheva E., Demin O.
    Poster
  • Amyloid Beta Distribution: Detailed Kinetic Model for Mouse scaled to monkey and human
    Subject: Alzheimer Ab Distribution
    Authors: Karelina T., Kazimirova E., Demin O., Lu Y., Nicholas T., Duvvuri S., Barton HA.
    Poster, Abstract

IV Meeting of Russian Biophysicists 2012, Nizhny Novgorod, Russia

 

  • Modeling of neutrophils dynamics in the presence of survival factors (on Russian)
    Subject: Neutrophils Survival
    Authors: Uvarovskii A., Speshilov G., Metelkin E.
    Download materials, abstract, presentation
  • Modeling of SN-38 inhibitor influence on cancer cell cycle (on Russian)
    Subject: Cell Cycle
    Authors: Pavlin S., Metelkin E.
    Download materials, abstract, presentation

DMDG meeting 2012, Loughborough, UK

 

ICSB 2011, Heidelberg/Mannheim, Germany

 

  • Prediction of the outcome of the PEG-IFN treatment of HCV using a viral dynamics model combined with population PK-PD methods
    Subject: HCV
    Authors: Vinogradova S.V. , Zhudenkov K.V. , Demin O.V., Benson N. , Van Der Graaf P. H., Karelina T.A.
    Download abstract, poster
  • Kinetic modeling of Escherichia coli central carbon metabolism
    Subject: Ecoli - central metabolism
    Authors: Peskov K.V., Mogilevskaya E.A., Demin O.V.
    Download abstract, poster

2d Joint NIAID-ISTC Workshop on Bioinformatics Tools and Innovation Through Collaboration 2011, Moscow, Russia

 

PAGE meeting 2011, Athens, Greece

 

  • A Systems Pharmacology Model of Anandamide Dynamics After FAAH Inhibitor Administration
    Subject: FAAH
    Authors: Metelkin E., Bagrova N., Demin O., Benson N.
    Download abstract, poster

EurasiaBio 2010, Moscow, Russia

 

  • Theophylline as HDAC – specific antioxidant: Hypothetical mechanism of anti-inflammatory effects in chronic obstructive pulmonary disease
    Subject: Theophylline
    Authors: Kosinsky Y., Mogilevskaya E., Demin O.
    Download poster, link to the website of the conference

IDDST 2009, Shanghai, China

 

Helmholtz German-Russian Workshop on Systems Biology 2008, Moscow, Russia

 

MCCMB 2007, Moscow, Russia

 

  • System modeling of EphB4/ephrinB2 signaling pathways
    Subject: Ephrin
    Authors: Demidenko A., Peskov K., Dorodnov A., Demin O., Nowlin D., Kraynov E., Vicini P., Luu K.
    Download poster
  • Modeling in Systems Biology: Progress, Problems and Applications to Biotechnology and Biomedicine
    Subject: Ecoli: purins, genetic regulation
    Author: Demin O.
    Download abstract, presentation

12 International Conference "Mathematics. Computer. Education." 2006, Dubna, Russia

 

Systems Biology: redefining BioThermoKinetics 2006, Trakai, Lithuania

 

Biomicroworld 2005, Badajoz, Spain

 

ICSB 2005, Boston, USA

 

12th International Conference on Intelligent Systems for Molecular Biology 2004, Glasgo, UK