Posters & Presentations

2021

AAIC 2021 Online

• Poster: Quantitative systems pharmacology model of amyloid and tau to explore efficacy of therapy targeting modified forms of amyloid
  Authors: Tatiana Karelina
• Poster: Quantitative systems pharmacology model of the effect of tau hyperphosphorylation on synaptic plasticity
  Authors: Stepan Lerner, Tatiana Karelina

SMB Annual Meeting

• Poster: Comparison of different implementations of lymphocyte proliferation in QSP models of immune response
  Authors: Oleg Demin
• Presentation: Implementation of variability or uncertainty in parameter values to validate QSP models
  Authors: Oleg Demin Jr
• Poster: Application of different approaches to generate virtual patient populations for QSP model of Erythropoiesis
  Authors: Galina Kolesova, Oleg Demin, Alexander Stepanov
• Poster: Specific lysis modeling and parameter extraction from experimental data
  Authors: Dmitry Shchelokov
• Presentation: Constrained Optimization Approach to Predictability Analysis in Bio-Mathematical Modeling
  Authors: Ivan Borisov

2020

ACoP11 Virtual Conference

• Poster: Stimulation of erythropoiesis with ESA or blood donation: QSP model
  Authors: Alexander Stepanov, Galina Lebedeva
• Poster: Quantitative mechanistic model for amyloid beta and tau protein role in synaptic plasticity
  Authors: Stepan Lerner, Tatiana Karelina
• Poster: Application of different approaches to generate virtual patient populations for QSP model of Erythropoiesis
  Authors: Galina Kolesova, Oleg Demin, Alexander Stepanov
• Poster: Practical Identifiability Analysis of QSP Models with LikelihoodProfiler
  Authors: Ivan Borisov, Evgeny Metelkin
• Poster: “Heta compiler” is a framework for the development and management of Quantitative Systems Pharmacology modeling platforms
  Authors: Evgeny Metelkin
• Poster: Monoclonal antibody therapy efficacy can be boosted by combinations with other treatments: predictions from integrated Alzheimer’s disease QSP platform
  Authors: Tatiana Karelina, Stepan Lerner
• Poster: Unified approach for in vitro data based parameters estimation
  Authors: Veronika Musatova, Oleg Demin, Svetlana Rubina
• Poster: CYTOCON as a tool to collect, compare and visualize available data on cells and cytokine concentrations in humans
  Authors: Vlad Leonov, Ekaterina Mogilevskaia, Elita Gerasimuk, Nail Gizzatkulov, Oleg Demin

AAIC Virtual Event

• Poster: Description of amyloid beta influence on synaptic plasticity and tau hyperphosphorylation by mechanistic quantitative systems pharmacology model
  Authors: Stepan Lerner, Tatiana Karelina
• Poster: Quantitative systems pharmacology model of Alzheimer’s disease to study efficacy of combinatorial therapy on multiple pathology components
  Author: Tatiana Karelina

AACR Virtual Annual Meeting II

• Poster: Prediction and comparison of PD-1 receptor occupancy in the tumor after treatment with immune checkpoint inhibitors
  Authors: Dmitry Shchelokov, Oleg Demin Jr
• Poster: Prediction of target receptor occupancy for ALX148, a CD47 blocker, using mechanistic PK/RO modeling
  Authors:Elena Vasileva¹², Oleg Demin Jr²
  Affiliation: ¹ Lomonosov Moscow State University, Moscow, Russia; ²InSysBio, Moscow, Russia

121st ASCPT Annual meeting (cancelled in response to COVID-19 spread)

• Poster: Quantitative systems pharmacology model of Alzheimer’s disease predicts effect of tau directed immunotherapy on multiple biomarkers
  Authors: Tatiana Karelina, Oleg Demin

2019

61st ASH Annual Meeting & Exposition, Orlando, FL, US

• Poster: A Quantitative Systems Pharmacology (QSP) Model to Predict Receptor Occupancy of Bruton’s Tyrosine Kinase (BTK) Inhibitors in Peripheral Blood Mononuclear Cells, Bone Marrow and Lymph Nodes of Patients with B-Cell Malignancies
  Authors: Srikumar Sahasranaman¹, Oleg Demin Jr², Dmitry Shchelokov², Veronika Musatova², Nageshwar Budha¹, Ying Ou²
  Affiliation: ¹Clinical Pharmacology, BeiGene USA, Inc.; ²InSysBio, Moscow, Russia.

SITC 2019, National Harbor, MD, US

• Poster: Prediction of target occupancy in tumor after treatment with anti-PD1 antibodies using physiologically based pharmacokinetic modeling
  Authors: Oleg Demin Jr, Dmitry Shchelokov
• Poster: Quantitative systems pharmacology modeling of B-cell acute lymphoblastic leukemia treatment with bispecific T-cell engaging antibodies for investigation of bell-shaped dose response
  Authors: Oleg Demin Jr

ACoP10, Orlando, FL, US

• Presentation: AD pathology QSP platform: studying the interactions between different toxicity modules through the junction of mechanistic submodels
  Speaker: Tatiana Karelina
• Poster: Physiologically based pharmacokinetic and receptor occupancy (PBPK/RO) modeling of anti-PD1 monoclonal antibodies
  Authors: Oleg Demin Jr, Dmitry Shchelokov
• Poster: Investigation of bell-shaped dose response of bispecific T-cell engaging antibodies under physiological conditions
  Author: Oleg Demin Jr
• Poster: Quantitative systems pharmacology model of COPD progression with implemented standard of care treatments (LABA/ICS)
  Authors: Galina Lebedeva¹, Mikhail Benkov¹, Oleg Demin¹, Loveleena Bansal², Cibele Falkenberg², Martin Hingle³, Valeriu Damian²
  Affiliation: ¹InSysBio, Moscow, Russia; ²GSK, Collegeville, PA; ³GSK, Stevenage, UK
• Poster: LikelihoodProfiler is a software package for practical identifiability analysis for the large-scale dynamic models
  Authors: Ivan Borisov, Evgeny Metelkin
• Poster: Development of quantitative systems pharmacology  (QSP) model of systemic lupus erythematosus and its application to explore possible mechanisms of alterations in serum IFN1 resulting from anti-IFNAR1 treatment
  Authors: Sergey Smirnov¹, Alexsandra Diakonova¹, Oleg Demin¹, Christopher Morehouse², Dominic Sinibaldi², Raj Tummala³, Denison Kuruvilla⁴, Yen Len Chia⁴, Lorin K. Roskos², Wendy I. White²
  Affiliation: ¹InSysBio, Moscow, Russia; ²MedImmune, Gaithersburg, MD USA; ³AstraZeneca Gaithersburg, MD USA; ⁴MedImmune, San Francisco, CA USA
• Poster: Influence of neuronal protein degradation pathways on  tau pathology studied by Quantitative Systems Pharmacology model
  Authors: Mark Meerson¹, Tatiana Karelina¹ and Diana Сlausznitzer²
  Affiliation: ¹InSysBio, Moscow, Russia; ²AbbVie, Ludwigshaven, Germany
• Poster: From stem cell to erythrocyte and platelet: QSP model of erythropoiesis and thrombopoiesis for assessing the impact of pharmacological interventions
  Authors: Alexander Stepanov, Galina Lebedeva
• Poster: Workflow for development of QSP models of Immune Response requires appropriate software infrastructure
  Authors: Tatiana Karelina
, Sergey Smirnov, Galina Lebedeva, Oleg Demin Jr, Evgeny Metelkin, Nail Gizzatkulov
• Poster: ’Heta’ is a new declarative language to define the large-scale systems pharmacology and systems biology models
  Author: Evgeny Metelkin
• Poster: PBPK modeling for therapeutic nanoparticles loaded with drug: distribution and release
  Authors: Evgeny Metelkin, Oleg Demin
• Poster: In vitro to in vivo extrapolation of CD4 T cell polarization in lymph nodes using QSP modeling
  Authors: Oleg Demin, Svetlana Rubina, Dmitry Shchelokov, Oleg Demin Jr
• Poster: QSP model of human granulopoiesis and neutrophil homeostasis for assessment of pharmacological interventions
  Authors: Galina Lebedeva, Alexander Stepanov

PAGE 2019, Stockholm, Sweden

• Poster: Quantitative Systems Pharmacology model of key intraneuronal pathways regulating toxic protein accumulation
  Authors: Mark Meerson¹, Tatiana Karelina¹ and Diana Сlausznitzer²
  Affiliation: ¹InSysBio, Moscow, Russia, ²AbbVie, Ludwigshaven, Germany
• Poster: Physiologically based pharmacokinetic modeling of anti-PD-1 therapeutic antibodies
  Authors: Dmitry Shchelokov, Oleg Demin Jr
• Poster: Amyloid β in vitro prion properties and in vivo pathology exacerbation mechanisms studied by translation quantitative systems pharmacology model for prediction of anti-protofibril immunotherapy effects
  Author: Tatiana Karelina
• Poster: Application of different approaches to generate virtual patient populations for QSP model of physiologically based pharmacokinetic model of anti-PD-1 therapeutic antibodies
  Authors: Galina Kolesova, Oleg Demin, Evgeny Metelkin and Dmitry Shchelokov

PEGS 2019, Boston, MA, US

• Poster: Selection of First-in-Human Study Dose for Antibodies and Antibody Constructs Using Quantitative Systems Pharmacology Modeling
  Authors: Oleg Demin Jr, Dmitry Shchelokov
  

AACR Annual Meeting 2019, Atlanta, GA, US

• Poster: Quantitative systems pharmacology modeling of immunotherapies in B-cell acute lymphoblastic leukemia
  Authors: Oleg Demin Jr, Antonina Nikitich, Oleg Demin
  
• Poster: Implementation of inter-patient variability in semi-mechanistic model of melanoma treatment with vemurafenib
  Authors: Dmitry Shchelokov, Oleg Demin Jr, Oleg Demin
  

2018

BiotechClub, Moscow, Russia

• Presentation: Application of mathematical modeling in drug research and development
  Speaker: Oleg Demin
  
• Presentation: Application of QSP modeling in immuno-oncology
  Speaker: Oleg Demin Jr
  

ICSB 2018, Lyon, France

• Poster: SBML viewer is a tool for transformation of systems biology models to human-readable format
  Authors: Viktoria Tkachenko , Evgeny Metelkin
  
• Poster: An algorithm for practical identifiability analysis and confidence intervals evaluation based on constrained optimization
  Authors: Ivan Borisov, Evgeny Metelkin
  

ACoP9, San Diego, CA, US

• Presentation: Quantitative systems pharmacology model for amyloid pathology investigation
  Speaker: Tatiana Karelina
  
• Poster: Quantitative Systems Pharmacology (QSP) model of bispecific T-Cell engaging antibody constructs for Acute Myeloid Leukemia treatment
  Authors: Oleg Demin Jr¹, Svetlana Rubina¹, Theresa Yuraszeck², Khamir Mehta², Vaishali Chudasama², Matthias Klinger³, Cedric Dos Santos², Oleg Demin¹, Sergey Ermakov²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Amgen Inc., Thousand Oaks, CA, USA; ³Amgen Research (Munich), Germany
• Poster: Translational quantitative systems pharmacology model of tau pathology in human and mouse for immunotherapy investigation
  Authors: Tatiana Karelina, Alexander Stepanov
  
• Poster: Identification of parameters of QSP models responsible for observed variability in experimental data
  Authors: Galina Kolesova, Oleg Demin
  

AAIC 2018, Chicago, IL, USA

• Poster: Translational quantitative systems pharmacology model of tauopathies
  Authors: Tatiana Karelina, Alexander Stepanov
  
• Poster: Description of different amyloid toxic species and pathology progression by mechanistic quantitative systems pharmacology model
  Authors: Tatiana Karelina, Alexander Stepanov, Alena Zhukova
  

PAGE 2018, Montreux, Switzerland

• Poster: A semi-mechanistic model of targeted therapy for melanoma
  Authors: Dmitrii Shchelokov, Oleg Demin Jr
  
• Poster: Simulations of tau-targeted therapies using quantitative systems pharmacology model of tau pathology
  Authors: Tatiana Karelina, Alexander Stepanov, Oleg Demin
  
• Poster: Modeling of amyloid accumulation in subjects at risk of Alzheimer’s disease under BACE inhibition treatment
  Authors: Etienne Pigeolet¹, Konstantinos Biliouris², Ulf Neumann³, Alexandra Urusova⁴, Oleg Demin⁴, Tatiana Karelina⁴
  Affiliation: ¹Novartis Pharma AG, Basel, Switzerland; ²Novartis Institute for Biomedical Research, Cambridge, USA; ³Novartis Institute for Biomedical Research, Basel, Switzerland; ⁴InSysBio, Moscow, Russia

AAT-AD/PD Focus Meeting, Torino, Italy

• Presentation: In silico implementation of tauopathy transgenic mouse model
  Speaker: Alexander Stepanov
  

ASCPT 2018, Orlando, FL, USA

• Poster: PBPK modeling for therapeutic nanoparticles loaded with drug: distribution and release
  Authors: Evgeny Metelkin, Oleg Demin
  
• Poster: Translational QSP model of amyloid beta allows to predict both short and long term response of AD patients to different therapies
  Authors: Tatiana Karelina¹, Oleg Demin¹, Oleg Demin Jr¹, Timothy Nicholas²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Pfizer Worldwide R&D, Groton, CT, USA
• Poster: Multiple myeloma quantitative systems pharmacology model: development and usage for pomalidomide influence evaluation
  Authors: Svetlana Rubina, Oleg Demin, Oleg Demin Jr
  

2017

ACoP8, Fort Lauderdale, FL, US

• Poster: Mechanistic model for the role of the microgliall cells in amyloid accumulation and its modulation by immunotherapy
  Authors: Tatiana Karelina¹, Alexander Stepanov¹, Theresa Yuraszeck², Dean Hickman², Steve Wood²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Amgen Inc., Thousand Oaks, CA, USA
• Poster: Tau propagation system pharmacology model based on three-component memory-retrieval system predicts heterogeneous response to immunotherapy in brain regions
  Authors: Tatiana Karelina¹, Alexander Stepanov¹, Timothy Nicholas²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Pfizer Worldwide R&D, Groton, CT, USA
• Poster: A Quantitative Systems Pharmacology Model of Asthma
  Authors: Sergey Smirnov¹, Galina Lebedeva¹, Oleg Demin¹, Tatiana Petukhova¹, Lourdes Cucurull-Sanchez², David Fairman²
  Affiliation: ¹InSysBio, Moscow, Russia; ²GSK Medicines Research Centre, Stevenage, UK
• Poster: Model-based analysis of clinical assays for assessing the efficacy of vaccines against Respiratory Syncytial Virus (RSV)
  Authors: Galina Lebedeva, Nikolai Pakhomov, Oleg Demin, Oleg Demin Jr
  
• Poster: Evaluation  of Potential Low-Dose Regimens of Oral Fixed-Dose Combination of Cytidine Deaminase Inhibitor E7727 with Decitabine (ASTX727-LD) to Minimize Decitabine-Mediated Neutropenia in Low-Risk MDS Subjects Using Systems Pharmacology Modeling
  Authors: Antonina Nikitich¹, Oleg Demin¹, Oleg Demin Jr¹, Aram Oganesian²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Astex Pharmaceuticals Inc., Pleasanton, CA

7th German-Russian Week of the Young Researcher, Moscow, Russia

• Poster: SbmlViewer is a visualization tool for systems biology modeling
  Authors: Viktoria Tkachenko, Evgeny Metelkin
  

AD/PD 2017, Vienna, Austria

• Poster: Amyloid toxicity and different mechanisms of action for amyloid-targeted treatments studied by quantitative systems pharmacology model
  Authors: Tatiana Karelina¹, Timothy Nicholas²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Pfizer Worldwide R&D, Groton, CT, USA

ASCPT 2017, Washington DC, US

• Poster: Mechanistic model of neutrophil cell dynamics and activation to inform systems pharmacology modeling of the immune response
  Authors: Galina Lebedeva, Sergey Smirnov, Evgeny Metelkin, Oleg Demin
  
• Poster: Mathematical description of multiple effects of regulatory molecules
  Authors: Sergey Smirnov, Evgeny Metelkin, Galina Lebedeva, Oleg Demin
  

2016

ACoP7, Bellevue, WA, US

• Presentation: Mechanistic approach to describe multiple effects of regulatory molecules on cell dynamics process in immune response
  Authors: Oleg Demin, Evgeny Metelkin, Galina Lebedeva, Sergey Smirnov
  
• Poster: Quantitative systems pharmacology model of amyloid pathology allows for clinical endpoint prediction and hypothesis testing
  Authors: Tatiana Karelina¹, Oleg Demin¹, Timothy Nicholas², Sridhar Duvvuri²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Pfizer Worldwide R&D, Groton, CT, USA
• Poster: Exploration of differences between mechanism-based PK/PD and systems pharmacology models
  Authors: Oleg Demin
  
• Poster: Modeling of immune response suppression by hepatitis C virus and nivolumab treatement in chronic hepatitis C patients using quantitative systems pharmacology approach
  Authors: Oleg Demin Jr
  

PAGE 2016, Lisboa, Portugal

• Poster: Population PK modeling of RPH-104, novel optimized IL-1 beta trap, and assessment of the immunogenicity effect on pharmacokinetics
  Authors: Evgeny Metelkin¹, Tatiana Petukhova¹, Oleg Demin¹, Elena Shipaeva², Mikhail Samsonov², Anna Krotkova², Yan Lavrovsky³
  Affiliation: ¹InSysBio, Moscow, Russia; ²JSC R-Pharm, Moscow, Russia; ³R-Pharm Overseas, Inc., San Diego, US

The International Liver Congress 2016, Barcelona, Spain

• Poster: Quantitative Systems Pharmacology model of Hepatitis C: Prediction of Results of Ongoing Clinical Trials of Direct Antiviral Agents Combination Therapies
  Authors: Oleg Demin Jr
  

ASCPT 2016, San Diego, CA, US

• Poster: Analysis of brain pharmacodynamics of gamma-secretase inhibitors using quantitative translational systems pharmacology model
  Authors: Tatiana Karelina¹, Oleg Demin¹, Timothy Nicholas², Sridhar Duvvuri²
  Affiliation: ¹InSysBio, Moscow, Russia; ²Pfizer Worldwide R&D, Groton, CT, USA
• Poster: Population modeling study for evaluation of effective and safe dose of RPH-104 for the treatment of Behcet’s syndrome and FMF
  Authors: Evgeny Metelkin¹, Tatiana Petukhova¹, Oleg Demin¹, Elena Shipaeva², Mikhail Samsonov², Anna Krotkova², Yan Lavrovsky³
  Affiliation: ¹InSysBio, Moscow, Russia; ²JSC R-Pharm, Moscow, Russia; ³R-Pharm Overseas, Inc., San Diego, US
• Poster: Systems Pharmacology Model Of Hepatitis C: Exploration Of Effect Of Combinations Of Direct Antiviral Agents On HCV Production During Treatment Of HCV Patients
  Authors: Oleg Demin Jr, Oleg Demin
  
• Poster: Population modeling and simulation of RPH-203 effects in the context of prevention of skeletal-related events in patients with bone metastases
  Authors: Evgeny Metelkin¹, Tatiana Petukhova¹, Oleg Demin¹, Shorena Archuadze², Galina Konopleva², Dmitry Koloda², Mikhail Samsonov²
  Affiliation: ¹InSysBio, Moscow, Russia; ²JSC R-Pharm, Moscow, Russia

2015

ASCPT 2015, New Orleans, LA, US

• Poster: Systems Pharmacology Modeling of Hypomethylating agents Decitabine and SGI-110 for Evaluation of AML treatment by targeting the S-phase with prolonged Pharmacokinetic exposures
  Authors: Aram Oganesian¹, Oleg Demin Jr², Antonina Nikitich², Oleg Demin² and Mohammad Azab¹
  Affiliation: ¹Astex Pharmaceuticals Inc., Dublin, CA, US; ²InSysBio, Moscow, Russia

20th Congress of EHA, Vienna, Austria

• Poster: Application of Systems Pharmacology Modeling for Evaluation of Therapies Effect on Blast Dynamics in Acute Lymphoblastic Leukemia
  Authors: Antonina Nikitich, Oleg Demin Jr

2014

Systems Pharmacology in Drug Discovery & Development, Noordwijkerhout, The Netherlands

• Poster: A systems pharmacology model of purine metabolism to explore novel options for the treatment of Gout
  Authors: Pinky Dua¹, Oleg Demin Jr², Viktor Sokolov², Tatiana Yakovleva², Oleg Demin², Piet van der Graaf^{1, 3}
  Affiliation: ¹Clinical Pharmacology, Pfizer Neusentis, Cambridge UK; ²InSysBio, Moscow, Russia; ³Leiden Academic Centre for Drug Research (LACDR), The Netherland

ASCPT 2014, Atlanta, GE, US

• Poster: Systems Pharmacology Modeling of Calcium and Phosphate Metabolism in Chronic Kidney Disease
  Authors: Antonina Bakhmutova, Oleg Demin Jr, Oleg Demin
  
• Poster: Development and Application of Systems Pharmacology Model to Predict Nausea Resulted from Administration GLP-1 Agonists
  Authors: Veronika Voronova, Oleg Demin Jr, Sergei Smirnov, Oleg Demin
  

EMBL-EBI Industry Systems Pharmacology Workshop, Cambridge, UK

• Presentation: Systems pharmacology modeling in drug research and development: application of modeling technique
  Speaker: Oleg Demin
  

2013

ACoP4, Fort Lauderdale, FL, US

• Poster: Development of a Human System Pharmacology Model to Characterize Diabetic Nephropathy Disease Progression and the Effect of Standard of Care Therapy
  Authors: Danny Chen¹, Veronika Voronova², Sergey Smirnov², Evgeny Metelkin², Ekaterina Goryacheva², Antonina Bahmutova², Oleg Demin²
  Affiliation: ¹Pfizer Inc. Cambridge, MA; ²InSysBio, Moscow, Russia

ASCPT 2013, Indianapolis, IN, US

• Presentation: Systems Pharmacology Modeling in Research and Development
  Speaker: Oleg Demin
  
• Poster: Exploration of molecular mechanisms underlying susceptibility of HCV patients to IFN-? therapy via systems pharmacology modeling
  Authors: Oleg Demin¹, Sergey Smirnov¹, Neil Benson², Piet H. van der Graaf², Victoria Flores², Ekaterina Goryacheva¹, Oleg Demin¹
  Affiliation: ¹InSysBio, Moscow, Russia; ²Pfizer, Sandwich, UK

Archive