Posters & Presentations
2019
61st ASH Annual Meeting & Exposition, Orlando, FL, US
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Poster: A Quantitative Systems Pharmacology (QSP) Model to Predict Receptor Occupancy of Bruton’s Tyrosine Kinase (BTK) Inhibitors in Peripheral Blood Mononuclear Cells, Bone Marrow and Lymph Nodes of Patients with B-Cell Malignancies
Authors: Srikumar Sahasranaman1, Oleg Demin Jr2, Dmitry Shchelokov2, Veronika Musatova2, Nageshwar Budha1, Ying Ou2
Affiliation: 1Clinical Pharmacology, BeiGene USA, Inc.; 2InSysBio, Moscow, Russia.
SITC 2019, National Harbor, MD, US
- Poster: Prediction of target occupancy in tumor after treatment with anti-PD1 antibodies using physiologically based pharmacokinetic modeling
Authors: Oleg Demin Jr, Dmitry Shchelokov - Poster: Quantitative systems pharmacology modeling of B-cell acute lymphoblastic leukemia treatment with bispecific T-cell engaging antibodies for investigation of bell-shaped dose response
Authors: Oleg Demin Jr
ACoP10, Orlando, FL, US
- Presentation: AD pathology QSP platform: studying the interactions between different toxicity modules through the junction of mechanistic submodels
Speaker: Tatiana Karelina - Poster: Physiologically based pharmacokinetic and receptor occupancy (PBPK/RO) modeling of anti-PD1 monoclonal antibodies
Authors: Oleg Demin Jr, Dmitry Shchelokov - Poster: Investigation of bell-shaped dose response of bispecific T-cell engaging antibodies under physiological conditions
Author: Oleg Demin Jr - Poster: Quantitative systems pharmacology model of COPD progression with implemented standard of care treatments (LABA/ICS)
Authors: Galina Lebedeva1, Mikhail Benkov1, Oleg Demin1, Loveleena Bansal2, Cibele Falkenberg2, Martin Hingle3, Valeriu Damian2
Affiliation: 1InSysBio, Moscow, Russia; 2GSK, Collegeville, PA; 3GSK, Stevenage, UK - Poster: LikelihoodProfiler is a software package for practical identifiability analysis for the large-scale dynamic models
Authors: Ivan Borisov, Evgeny Metelkin - Poster: Development of quantitative systems pharmacology (QSP) model of systemic lupus erythematosus and its application to explore possible mechanisms of alterations in serum IFN1 resulting from anti-IFNAR1 treatment
Authors: Sergey Smirnov1, Alexsandra Diakonova1, Oleg Demin1, Christopher Morehouse2, Dominic Sinibaldi2, Raj Tummala3, Denison Kuruvilla4, Yen Len Chia4, Lorin K. Roskos2, Wendy I. White2
Affiliation: 1InSysBio, Moscow, Russia; 2MedImmune, Gaithersburg, MD USA; 3AstraZeneca Gaithersburg, MD USA; 4MedImmune, San Francisco, CA USA - Poster: Influence of neuronal protein degradation pathways on tau pathology studied by Quantitative Systems Pharmacology model
Authors: Mark Meerson1, Tatiana Karelina1 and Diana Сlausznitzer2
Affiliation: 1InSysBio, Moscow, Russia; 2AbbVie, Ludwigshaven, Germany - Poster: From stem cell to erythrocyte and platelet: QSP model of erythropoiesis and thrombopoiesis for assessing the impact of pharmacological interventions
Authors: Alexander Stepanov, Galina Lebedeva - Poster: Workflow for development of QSP models of Immune Response requires appropriate software infrastructure
Authors: Oleg Demin, Sergey Smirnov, Galina Lebedeva, Oleg Demin Jr, Evgeny Metelkin, Nail Gizzatkulov - Poster: ’Heta’ is a new declarative language to define the large-scale systems pharmacology and systems biology models
Author: Evgeny Metelkin - Poster: PBPK modeling for therapeutic nanoparticles loaded with drug: distribution and release
Authors: Evgeny Metelkin, Oleg Demin - Poster: In vitro to in vivo extrapolation of CD4 T cell polarization in lymph nodes using QSP modeling
Authors: Oleg Demin, Svetlana Rubina, Dmitry Shchelokov, Oleg Demin Jr - Poster: QSP model of human granulopoiesis and neutrophil homeostasis for assessment of pharmacological interventions
Authors: Galina Lebedeva, Alexander Stepanov
PAGE 2019, Stockholm, Sweden
- Poster: Quantitative Systems Pharmacology model of key intraneuronal pathways regulating toxic protein accumulation
Authors: Mark Meerson1, Tatiana Karelina1 and Diana Сlausznitzer2
Affiliation: 1InSysBio, Moscow, Russia, 2AbbVie, Ludwigshaven, Germany - Poster: Physiologically based pharmacokinetic modeling of anti-PD-1 therapeutic antibodies
Authors: Dmitry Shchelokov, Oleg Demin Jr - Poster: Amyloid β in vitro prion properties and in vivo pathology exacerbation mechanisms studied by translation quantitative systems pharmacology model for prediction of anti-protofibril immunotherapy effects
Author: Tatiana Karelina - Poster: Application of different approaches to generate virtual patient populations for QSP model of physiologically based pharmacokinetic model of anti-PD-1 therapeutic antibodies
Authors: Galina Kolesova, Oleg Demin, Evgeny Metelkin and Dmitry Shchelokov
PEGS 2019, Boston, MA, US
- Poster: Selection of First-in-Human Study Dose for Antibodies and Antibody Constructs Using Quantitative Systems Pharmacology Modeling
Authors: Oleg Demin Jr, Dmitry Shchelokov
AACR Annual Meeting 2019, Atlanta, GA, US
- Poster: Quantitative systems pharmacology modeling of immunotherapies in B-cell acute lymphoblastic leukemia
Authors: Oleg Demin Jr, Antonina Nikitich, Oleg Demin - Poster: Implementation of inter-patient variability in semi-mechanistic model of melanoma treatment with vemurafenib
Authors: Dmitry Shchelokov, Oleg Demin Jr, Oleg Demin
2018
BiotechClub, Moscow, Russia
- Presentation: Application of mathematical modeling in drug research and development
Speaker: Oleg Demin - Presentation: Application of QSP modeling in immuno-oncology
Speaker: Oleg Demin Jr
ICSB 2018, Lyon, France
- Poster: SBML viewer is a tool for transformation of systems biology models to human-readable format
Authors: Viktoria Tkachenko , Evgeny Metelkin - Poster: An algorithm for practical identifiability analysis and confidence intervals evaluation based on constrained optimization
Authors: Ivan Borisov, Evgeny Metelkin
ACoP9, San Diego, CA, US
- Presentation: Quantitative systems pharmacology model for amyloid pathology investigation
Speaker: Tatiana Karelina - Poster: Quantitative Systems Pharmacology (QSP) model of bispecific T-Cell engaging antibody constructs for Acute Myeloid Leukemia treatment
Authors: Oleg Demin Jr1, Svetlana Rubina1, Theresa Yuraszeck2, Khamir Mehta2, Vaishali Chudasama2, Matthias Klinger3, Cedric Dos Santos2, Oleg Demin1, Sergey Ermakov2
Affiliation: 1InSysBio, Moscow, Russia; 2Amgen Inc., Thousand Oaks, CA, USA; 3Amgen Research (Munich), Germany - Poster: Translational quantitative systems pharmacology model of tau pathology in human and mouse for immunotherapy investigation
Authors: Tatiana Karelina, Alexander Stepanov - Poster: Identification of parameters of QSP models responsible for observed variability in experimental data
Authors: Galina Kolesova, Oleg Demin
AAIC 2018, Chicago, IL, USA
- Poster: Translational quantitative systems pharmacology model of tauopathies
Authors: Tatiana Karelina, Alexander Stepanov - Poster: Description of different amyloid toxic species and pathology progression by mechanistic quantitative systems pharmacology model
Authors: Tatiana Karelina, Alexander Stepanov, Alena Zhukova
PAGE 2018, Montreux, Switzerland
- Poster: A semi-mechanistic model of targeted therapy for melanoma
Authors: Dmitrii Shchelokov, Oleg Demin Jr - Poster: Simulations of tau-targeted therapies using quantitative systems pharmacology model of tau pathology
Authors: Tatiana Karelina, Alexander Stepanov, Oleg Demin - Poster: Modeling of amyloid accumulation in subjects at risk of Alzheimer’s disease under BACE inhibition treatment
Authors: Etienne Pigeolet1, Konstantinos Biliouris2, Ulf Neumann3, Alexandra Urusova4, Oleg Demin4, Tatiana Karelina4
Affiliation: 1Novartis Pharma AG, Basel, Switzerland; 2Novartis Institute for Biomedical Research, Cambridge, USA; 3Novartis Institute for Biomedical Research, Basel, Switzerland; 4InSysBio, Moscow, Russia
AAT-AD/PD Focus Meeting, Torino, Italy
- Presentation: In silico implementation of tauopathy transgenic mouse model
Speaker: Alexander Stepanov
ASCPT 2018, Orlando, FL, USA
- Poster: PBPK modeling for therapeutic nanoparticles loaded with drug: distribution and release
Authors: Evgeny Metelkin, Oleg Demin - Poster: Translational QSP model of amyloid beta allows to predict both short and long term response of AD patients to different therapies
Authors: Tatiana Karelina1, Oleg Demin1, Oleg Demin Jr1, Timothy Nicholas2
Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer Worldwide R&D, Groton, CT, USA - Poster: Multiple myeloma quantitative systems pharmacology model: development and usage for pomalidomide influence evaluation
Authors: Svetlana Rubina, Oleg Demin, Oleg Demin Jr
2017
ACoP8, Fort Lauderdale, FL, US
- Poster: Mechanistic model for the role of the microgliall cells in amyloid accumulation and its modulation by immunotherapy
Authors: Tatiana Karelina1, Alexander Stepanov1, Theresa Yuraszeck2, Dean Hickman2, Steve Wood2
Affiliation: 1InSysBio, Moscow, Russia; 2Amgen Inc., Thousand Oaks, CA, USA - Poster: Tau propagation system pharmacology model based on three-component memory-retrieval system predicts heterogeneous response to immunotherapy in brain regions
Authors: Tatiana Karelina1, Alexander Stepanov1, Timothy Nicholas2
Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer Worldwide R&D, Groton, CT, USA - Poster: A Quantitative Systems Pharmacology Model of Asthma
Authors: Sergey Smirnov1, Galina Lebedeva1, Oleg Demin1, Tatiana Petukhova1, Lourdes Cucurull-Sanchez2, David Fairman2
Affiliation: 1InSysBio, Moscow, Russia; 2GSK Medicines Research Centre, Stevenage, UK - Poster: Model-based analysis of clinical assays for assessing the efficacy of vaccines against Respiratory Syncytial Virus (RSV)
Authors: Galina Lebedeva, Nikolai Pakhomov, Oleg Demin, Oleg Demin Jr - Poster: Evaluation of Potential Low-Dose Regimens of Oral Fixed-Dose Combination of Cytidine Deaminase Inhibitor E7727 with Decitabine (ASTX727-LD) to Minimize Decitabine-Mediated Neutropenia in Low-Risk MDS Subjects Using Systems Pharmacology Modeling
Authors: Antonina Nikitich1, Oleg Demin1, Oleg Demin Jr1, Aram Oganesian2
Affiliation: 1InSysBio, Moscow, Russia; 2Astex Pharmaceuticals Inc., Pleasanton, CA
7th German-Russian Week of the Young Researcher, Moscow, Russia
- Poster: SbmlViewer is a visualization tool for systems biology modeling
Authors: Viktoria Tkachenko, Evgeny Metelkin
AD/PD 2017, Vienna, Austria
- Poster: Amyloid toxicity and different mechanisms of action for amyloid-targeted treatments studied by quantitative systems pharmacology model
Authors: Tatiana Karelina1, Timothy Nicholas2
Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer Worldwide R&D, Groton, CT, USA
ASCPT 2017, Washington DC, US
- Poster: Mechanistic model of neutrophil cell dynamics and activation to inform systems pharmacology modeling of the immune response
Authors: Galina Lebedeva, Sergey Smirnov, Evgeny Metelkin, Oleg Demin - Poster: Mathematical description of multiple effects of regulatory molecules
Authors: Sergey Smirnov, Evgeny Metelkin, Galina Lebedeva, Oleg Demin
2016
ACoP7, Bellevue, WA, US
- Presentation: Mechanistic approach to describe multiple effects of regulatory molecules on cell dynamics process in immune response
Authors: Oleg Demin, Evgeny Metelkin, Galina Lebedeva, Sergey Smirnov - Poster: Quantitative systems pharmacology model of amyloid pathology allows for clinical endpoint prediction and hypothesis testing
Authors: Tatiana Karelina1, Oleg Demin1, Timothy Nicholas2, Sridhar Duvvuri2
Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer Worldwide R&D, Groton, CT, USA - Poster: Exploration of differences between mechanism-based PK/PD and systems pharmacology models
Authors: Oleg Demin - Poster: Modeling of immune response suppression by hepatitis C virus and nivolumab treatement in chronic hepatitis C patients using quantitative systems pharmacology approach
Authors: Oleg Demin Jr
PAGE 2016, Lisboa, Portugal
- Poster: Population PK modeling of RPH-104, novel optimized IL-1 beta trap, and assessment of the immunogenicity effect on pharmacokinetics
Authors: Evgeny Metelkin1, Tatiana Petukhova1, Oleg Demin1, Elena Shipaeva2, Mikhail Samsonov2, Anna Krotkova2, Yan Lavrovsky3
Affiliation: 1InSysBio, Moscow, Russia; 2JSC R-Pharm, Moscow, Russia; 3R-Pharm Overseas, Inc., San Diego, US
The International Liver Congress 2016, Barcelona, Spain
- Poster: Quantitative Systems Pharmacology model of Hepatitis C: Prediction of Results of Ongoing Clinical Trials of Direct Antiviral Agents Combination Therapies
Authors: Oleg Demin Jr
ASCPT 2016, San Diego, CA, US
- Poster: Analysis of brain pharmacodynamics of gamma-secretase inhibitors using quantitative translational systems pharmacology model
Authors: Tatiana Karelina1, Oleg Demin1, Timothy Nicholas2, Sridhar Duvvuri2
Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer Worldwide R&D, Groton, CT, USA - Poster: Population modeling study for evaluation of effective and safe dose of RPH-104 for the treatment of Behcet’s syndrome and FMF
Authors: Evgeny Metelkin1, Tatiana Petukhova1, Oleg Demin1, Elena Shipaeva2, Mikhail Samsonov2, Anna Krotkova2, Yan Lavrovsky3
Affiliation: 1InSysBio, Moscow, Russia; 2JSC R-Pharm, Moscow, Russia; 3R-Pharm Overseas, Inc., San Diego, US - Poster: Systems Pharmacology Model Of Hepatitis C: Exploration Of Effect Of Combinations Of Direct Antiviral Agents On HCV Production During Treatment Of HCV Patients
Authors: Oleg Demin Jr, Oleg Demin - Poster: Population modeling and simulation of RPH-203 effects in the context of prevention of skeletal-related events in patients with bone metastases
Authors: Evgeny Metelkin1, Tatiana Petukhova1, Oleg Demin1, Shorena Archuadze2, Galina Konopleva2, Dmitry Koloda2, Mikhail Samsonov2
Affiliation: 1InSysBio, Moscow, Russia; 2JSC R-Pharm, Moscow, Russia
2015
ASCPT 2015, New Orleans, LA, US
- Poster: Systems Pharmacology Modeling of Hypomethylating agents Decitabine and SGI-110 for Evaluation of AML treatment by targeting the S-phase with prolonged Pharmacokinetic exposures
Authors: Aram Oganesian1, Oleg Demin Jr2, Antonina Nikitich2, Oleg Demin2 and Mohammad Azab1
Affiliation: 1Astex Pharmaceuticals Inc., Dublin, CA, US; 2InSysBio, Moscow, Russia
20th Congress of EHA, Vienna, Austria
- Poster: Application of Systems Pharmacology Modeling for Evaluation of Therapies Effect on Blast Dynamics in Acute Lymphoblastic Leukemia
Authors: Antonina Nikitich, Oleg Demin Jr
2014
Systems Pharmacology in Drug Discovery & Development, Noordwijkerhout, The Netherlands
- Poster: A systems pharmacology model of purine metabolism to explore novel options for the treatment of Gout
Authors: Pinky Dua1, Oleg Demin Jr2, Viktor Sokolov2, Tatiana Yakovleva2, Oleg Demin2, Piet van der Graaf1, 3
Affiliation: 1Clinical Pharmacology, Pfizer Neusentis, Cambridge UK; 2InSysBio, Moscow, Russia; 3Leiden Academic Centre for Drug Research (LACDR), The Netherland
ASCPT 2014, Atlanta, GE, US
- Poster: Systems Pharmacology Modeling of Calcium and Phosphate Metabolism in Chronic Kidney Disease
Authors: Antonina Bakhmutova, Oleg Demin Jr, Oleg Demin - Poster: Development and Application of Systems Pharmacology Model to Predict Nausea Resulted from Administration GLP-1 Agonists
Authors: Veronika Voronova, Oleg Demin Jr, Sergei Smirnov, Oleg Demin
EMBL-EBI Industry Systems Pharmacology Workshop, Cambridge, UK
- Presentation: Systems pharmacology modeling in drug research and development: application of modeling technique
Speaker: Oleg Demin
2013
ACoP4, Fort Lauderdale, FL, US
- Poster: Development of a Human System Pharmacology Model to Characterize Diabetic Nephropathy Disease Progression and the Effect of Standard of Care Therapy
Authors: Danny Chen1, Veronika Voronova2, Sergey Smirnov2, Evgeny Metelkin2, Ekaterina Goryacheva2, Antonina Bahmutova2, Oleg Demin2
Affiliation: 1Pfizer Inc. Cambridge, MA; 2InSysBio, Moscow, Russia
ASCPT 2013, Indianapolis, IN, US
- Presentation: Systems Pharmacology Modeling in Research and Development
Speaker: Oleg Demin - Poster: Exploration of molecular mechanisms underlying susceptibility of HCV patients to IFN-? therapy via systems pharmacology modeling
Authors: Oleg Demin1, Sergey Smirnov1, Neil Benson2, Piet H. van der Graaf2, Victoria Flores2, Ekaterina Goryacheva1, Oleg Demin1
Affiliation: 1InSysBio, Moscow, Russia; 2Pfizer, Sandwich, UK